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There is no standard chemotherapeutic regimen for ENKTL. Recently, the efficacy of<jats:sc>l<\/jats:sc>\u2010asparaginase in ENKTL has been confirmed. A series of<jats:sc>l<\/jats:sc>\u2010asparaginase\u2010containing chemotherapeutic regimens have been studied in clinical trials and have significantly improved the efficacy and prognosis for patients with ENKTL. This review will focus on pharmacology of<jats:sc>l<\/jats:sc>\u2010asparaginase, the efficacy of a series of<jats:sc>l<\/jats:sc>\u2010asparaginase\u2010containing regimens in the treatment of ENKTL and future clinical study directions of<jats:sc>l<\/jats:sc>\u2010asparaginase\u2010containing regimens in ENKTL. 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