{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T02:28:42Z","timestamp":1782872922807,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T00:00:00Z","timestamp":1437696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Einstein Montefiore Center for AIDS Research","award":["NIH AI-051519"],"award-info":[{"award-number":["NIH AI-051519"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The significance of HIV associated paraproteins and their risk of progression to hematological malignancies remains unclear. We compared the development of hematological malignancies among HIV+ (n\u2009=\u2009266) and HIV\u2212 (n\u2009=\u2009537) patients with monoclonal gammopathies. HIV+ and HIV\u2212 patients with a positive serum protein electrophoresis test (SPEP) were studied. HIV+ SPEP+ were more likely to have faint and oligoclonal paraproteins (F\u2010SPEP) and less likely to have discrete bands (D\u2010SPEP) compared to HIV\u2212 SPEP+. The incidence of hematological malignancies was significantly lower in the HIV+ compared to the HIV\u2212 (6.4% vs 15.4%, p\u2009&lt;\u20090.0002). Upon subgroup analysis, the lower incidence of hematological malignancies was noted for HIV+ patients with F\u2010SPEP but not for those with D\u2010SPEP. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.2247","type":"journal-article","created":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T06:29:23Z","timestamp":1437719363000},"page":"64-68","source":"Crossref","is-referenced-by-count":5,"title":["Retrospective study of the prevalence and progression of monoclonal gammopathy in HIV positive versus HIV negative patients"],"prefix":"10.1002","volume":"35","author":[{"given":"Erin","family":"Jou","sequence":"first","affiliation":[{"name":"Division of Hematology, Department of Oncology Montefiore Medical Center\/Albert Einstein College of Medicine  Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleg","family":"Gligich","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Oncology Montefiore Medical Center\/Albert Einstein College of Medicine  Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvita C. Y.","family":"Chan","sequence":"additional","affiliation":[{"name":"Partner State Key Laboratory of Oncology in South China, Sir Y K Pao Centre for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute and Prince of Wales Hospital The Chinese University of Hong Kong  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diwakar","family":"Mohan","sequence":"additional","affiliation":[{"name":"Department of International Health Johns Hopkins Bloomberg School of Public Health  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uriel R.","family":"Felsen","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine Montefiore Medical Center\/Albert Einstein College of Medicine  Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabarish","family":"Ayyappan","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology University Hospitals Case Medical Center  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henny H.","family":"Billett","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Oncology Montefiore Medical Center\/Albert Einstein College of Medicine  Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin P.","family":"Hui","sequence":"additional","affiliation":[{"name":"Partner State Key Laboratory of Oncology in South China, Sir Y K Pao Centre for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute and Prince of Wales Hospital The Chinese University of Hong Kong  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony T.","family":"Chan","sequence":"additional","affiliation":[{"name":"Partner State Key Laboratory of Oncology in South China, Sir Y K Pao Centre for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute and Prince of Wales Hospital The Chinese University of Hong Kong  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radha","family":"Raghupathy","sequence":"additional","affiliation":[{"name":"Partner State Key Laboratory of Oncology in South China, Sir Y K Pao Centre for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute and Prince of Wales Hospital The Chinese University of Hong Kong  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa01133202"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2400875"},{"issue":"2","key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1093\/clinchem\/35.2.338a","article-title":"Follow\u2010up of monoclonal gammopathies in asymptomatic HIV\u2010infected subjects","volume":"35","author":"Lefrere 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