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We conducted a systematic review and meta\u2010analysis to examine the associations between statin use and NHL risk and survival. We searched multiple literature sources up to October 2014 and identified 10 studies on the risk of diagnosis with NHL and 9 studies on survival. Random effects model was used to calculate pooled odds ratio (PORs) for risk and pooled hazard ratio (PHR) for survival. Heterogeneity among studies was examined using the Tau\u2010squared and the I\u2010squared (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>) tests. Statin use was associated with reduced risk for total NHL (POR\u2009=\u20090.82, 95% CI 0.69\u20130.99). Among statin users, there was a lower incidence risk for marginal zone lymphoma (POR\u2009=\u20090.54, 95% CI 0.31\u20130.94), but this was not observed for other types of NHL. However, statin use did not affect overall survival (PHR\u2009=\u20091.02, 95% CI 0.99\u20131.06) or event\u2010free survival (PHR\u2009=\u20090.99, 95% CI 0.87\u20131.12) in diffuse large B\u2010cell lymphoma. There is suggestive epidemiological evidence that statins decrease the risk of NHL, but they do not influence survival in NHL patients. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.2265","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T13:31:28Z","timestamp":1445347888000},"page":"206-214","source":"Crossref","is-referenced-by-count":20,"title":["Associations between statin use and non\u2010Hodgkin lymphoma (NHL) risk and survival: a meta\u2010analysis"],"prefix":"10.1002","volume":"35","author":[{"given":"Xibiao","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Community Health Sciences, College of Medicine, Faculty of Health Sciences University of Manitoba  Winnipeg Manitoba Canada"},{"name":"Centre for Healthcare Innovation University of Manitoba\/Winnipeg Regional Health Authority  Winnipeg Manitoba Canada"},{"name":"Vaccine and Drug Evaluation Centre University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayat","family":"Mneina","sequence":"additional","affiliation":[{"name":"Department of Community Health Sciences, College of Medicine, Faculty of Health Sciences University of Manitoba  Winnipeg Manitoba Canada"},{"name":"Vaccine and Drug Evaluation Centre University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, Faculty of Health Sciences University of Manitoba  Winnipeg Manitoba Canada"},{"name":"CancerCare Manitoba  Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salaheddin M.","family":"Mahmud","sequence":"additional","affiliation":[{"name":"Department of Community Health Sciences, College of Medicine, Faculty of Health Sciences University of Manitoba  Winnipeg Manitoba Canada"},{"name":"Centre for Healthcare Innovation University of Manitoba\/Winnipeg Regional Health Authority  Winnipeg Manitoba Canada"},{"name":"Vaccine and Drug Evaluation Centre University of Manitoba  Winnipeg Manitoba Canada"},{"name":"College of Pharmacy, Faculty of Health Sciences University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,20]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"2009 Manitoba Centre for Health Policy Winnipeg MB A Kozyrskyj C Raymond M Dahl Effects of Manitoba Pharmacare formulary policy on utilization of prescription medications"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23722"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10403"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1751"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-09-048033"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2005.11.012"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-2953"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328349c67a"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0866"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:CACO.0000027506.55846.5d"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000254694.03027.a1"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.02.027"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.15.2363"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2006.00153.x"},{"issue":"1","key":"e_1_2_6_16_1","first-page":"55","article-title":"Lovastatin enhances in vitro radiation\u2010induced apoptosis of rat B\u2010cell lymphoma cells","volume":"24","author":"Rozados VR","year":"2005","journal-title":"J Exp Clin Cancer Res"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2013.04.006"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0305149101"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0050064"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2011.574752"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-010-0926-0"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp490"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28299"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2010.486877"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.4245"},{"issue":"15","key":"e_1_2_6_26_1","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1001\/jama.283.15.2008","article-title":"Meta\u2010analysis of observational studies in epidemiology: a proposal for reporting. 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