{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:37:07Z","timestamp":1760985427543},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Burkitt's lymphoma (BL) is an aggressive non\u2010Hodgkin's B\u2010cell lymphoma with an extremely short doubling time that often presents in extra nodal sites or as an acute leukaemia. Nowadays, with the rapid response to chemotherapy and the diffuse nature of BL, there is no established role for radiation therapy (RT) even in localized disease. Regarding the relapsed\/refractory BL, the treatment recommendations remain undefined.<\/jats:p><jats:p>We present a 56\u2010year\u2010old woman, diagnosed with BL refractory to 6\u2009cycles of R\u2010CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone), who had disease progression on R\u2010DHAP (rituximab, dexamethasone, high dose cytarabine and cisplatin) with intrathecal methotrexate, then a partial response on RICE (rituximab, ifosfamide, carboplatin and etoposide). Patient received high dose chemotherapy and autologous haematopoietic stem cell transplantation. Then, she was treated with hyperfractionated involved\u2010field RT regimen. Currently, the patient remains disease free for around 2\u2009years after remission.<\/jats:p><jats:p>We acknowledge that RT is not a standard treatment of BL, especially in patients who attain complete response (CR) after first\u2010line multi\u2010agent chemotherapy or even in those who have a CR after second\u2010line chemotherapy pre\u2010transplant. Yet, the use of a superfractionated regimen of consolidative radiation could be justified in the treatment of recurrent\/refractory localized BL who do not achieve a CR even with second\u2010line salvage chemotherapy. Radiation therapy in this context, given that it is a well\u2010tolerated treatment, is a modality worthy of being re\u2010considered in relapsed\/refractory BL. Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.2294","type":"journal-article","created":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T05:13:38Z","timestamp":1463462018000},"page":"856-860","source":"Crossref","is-referenced-by-count":3,"title":["Hyperfractionated radiation therapy in Burkitt's lymphoma: a reconsideration aspect"],"prefix":"10.1002","volume":"35","author":[{"given":"Khalil","family":"Charafeddine","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara","family":"Hilal","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Bazarbachi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nassima","family":"Salame","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bassem","family":"Youssef","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"262","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Swerdlow SH","year":"2008"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt058"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-12-475558"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1269\/jrr.15.25"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08947.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21753"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12736"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.9.2465"},{"issue":"8","key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1182\/blood.V90.8.2921","article-title":"High\u2010dose chemotherapy with autologous bone marrow rescue in children with poor\u2010risk Burkitt's lymphoma: a report from the European Lymphoma Bone Marrow Transplantation Registry","volume":"90","author":"Ladenstein R","year":"1997","journal-title":"Blood"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(77)90149-3"},{"issue":"6","key":"e_1_2_6_12_1","first-page":"609","article-title":"Hyperfractionated radiotherapy for Burkitt\u2010type lymphoma","volume":"38","author":"Pilecki B","year":"1991","journal-title":"Radiobiological aspects. Neoplasma"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.09.030"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhon.2294","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhon.2294","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.2294","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T16:59:51Z","timestamp":1695488391000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.2294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,17]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/hon.2294"],"URL":"https:\/\/doi.org\/10.1002\/hon.2294","archive":["Portico"],"relation":{},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,17]]}}}