{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:14:35Z","timestamp":1762899275806},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T00:00:00Z","timestamp":1465516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["211.475\/2015"],"award-info":[{"award-number":["211.475\/2015"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In pediatric acute leukemias, reciprocal chromosomal translocations frequently cause gene fusions involving the lysine (K)\u2010specific methyltransferase 2A gene (<jats:italic>KMT2A<\/jats:italic>, also known as <jats:italic>MLL<\/jats:italic>). Specific <jats:italic>KMT2A<\/jats:italic> fusion partners are associated with the disease phenotype (lymphoblastic vs. myeloid), and the type of <jats:italic>KMT2A<\/jats:italic> rearrangement also has prognostic implications. However, the <jats:italic>KMT2A<\/jats:italic> partner gene cannot always be identified by banding karyotyping. We sought to identify such partner genes in 13 cases of childhood leukemia with uninformative karyotypes by combining molecular techniques, including multicolor banding FISH, reverse\u2010transcriptase PCR, and long\u2010distance inverse PCR. Of the <jats:italic>KMT2A<\/jats:italic> fusion partner genes, <jats:italic>MLLT3<\/jats:italic> was present in five patients, all with acute lymphoblastic leukemia, <jats:italic>MLLT1<\/jats:italic> in two patients, and <jats:italic>MLLT10<\/jats:italic>, <jats:italic>MLLT4<\/jats:italic>, <jats:italic>MLLT11<\/jats:italic>, and <jats:italic>AFF1<\/jats:italic> in one patient each. Reciprocal reading by long\u2010distance inverse PCR also disclosed <jats:italic>KMT2A<\/jats:italic> fusions with <jats:italic>PITPNA<\/jats:italic> in one patient, with <jats:italic>LOC100132273<\/jats:italic> in another patient, and with DNA sequences not compatible with any gene in three patients. The most common <jats:italic>KMT2A<\/jats:italic> breakpoint region was intron\/exon 9 (3\/8 patients), followed by intron\/exon 11 and 10. Finally, multicolor banding revealed breakpoints in other chromosomes whose biological and prognostic implications remain to be determined. We conclude that the combination of molecular techniques used in this study can efficiently identify <jats:italic>KMT2A<\/jats:italic> fusion partners in complex pediatric acute leukemia karyotypes. Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.2299","type":"journal-article","created":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T09:20:54Z","timestamp":1465550454000},"page":"760-768","source":"Crossref","is-referenced-by-count":10,"title":["Molecular characterization of <i>KMT2A<\/i> fusion partner genes in 13 cases of pediatric leukemia with complex or cryptic karyotypes"],"prefix":"10.1002","volume":"35","author":[{"given":"Daniela R.","family":"Ney Garcia","sequence":"first","affiliation":[{"name":"Clinical Medicine Postgraduate Program College of Medicine, Federal University of Rio de Janeiro  Rio de Janeiro Brazil"},{"name":"Cytogenetics Department, Bone Marrow Transplantation Unit National Cancer Institute  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana T.","family":"de Souza","sequence":"additional","affiliation":[{"name":"Cytogenetics Department, Bone Marrow Transplantation Unit National Cancer Institute  Rio de Janeiro Brazil"},{"name":"Oncology Post Graduation Program National Cancer Institute  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda F.","family":"de Figueiredo","sequence":"additional","affiliation":[{"name":"Cytogenetics Department, Bone Marrow Transplantation Unit National Cancer Institute  Rio de Janeiro Brazil"},{"name":"Oncology Post Graduation Program National Cancer Institute  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moneeb A. 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P.","family":"Land","sequence":"additional","affiliation":[{"name":"Clinical Medicine Postgraduate Program College of Medicine, Federal University of Rio de Janeiro  Rio de Janeiro Brazil"},{"name":"Martag\u00e3o Gesteira Institute of Pediatrics and Child Development Federal University of Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Liehr","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics Jena University Hospital  Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raul C.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Oncology St. Jude Children's Research Hospital, Memphis  Tennessee United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luiza Macedo","family":"Silva","sequence":"additional","affiliation":[{"name":"Clinical Medicine Postgraduate Program College of Medicine, Federal University of Rio de Janeiro  Rio de Janeiro Brazil"},{"name":"Cytogenetics Department, Bone Marrow Transplantation Unit National Cancer Institute  Rio de Janeiro Brazil"},{"name":"Oncology Post Graduation Program National Cancer Institute  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2009.01167.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.30.7405"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2007.07.005"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201400449"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12442"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2217\/ijh.13.20"},{"issue":"11","key":"e_1_2_7_8_1","first-page":"2165","article-title":"The MLL recombinome of acute leukemias in 2013","volume":"27","author":"Meyer C","year":"2013","journal-title":"Leukemia 2013"},{"key":"e_1_2_7_9_1","first-page":"335","article-title":"Microdissection based high resolution multicolor banding for all 24 human chromosomes","volume":"9","author":"Liehr T","year":"2002","journal-title":"Int J Mol Med"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2010.02.011"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2011.08.003"},{"key":"e_1_2_7_12_1","volume-title":"ISCN 2013: An International System for Human Cytogenetic Nomenclature","author":"Shaffer LG","year":"2013"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(03)00099-2"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.03.029"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2015.02.002"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2011.12.009"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12250"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(00)00439-8"},{"key":"e_1_2_7_19_1","unstructured":"Atlas of Genetics and Cytogenetics in Oncology and Haematology. 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