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Although major validated risk factors for central nervous system dissemination are clinical, concomitant MYC\/BCL2 rearrangements as well as MYC\/BCL2 protein expression have been recently associated with an increased risk of this complication. Here we present the first case, to our knowledge, of a MYC\/BCL6\u2010positive double\u2010hit diffuse large B\u2010cell lymphoma relapsing in the leptomeninges that achieved an outstanding durable remission with single\u2010agent lenalidomide following salvage chemotherapy. Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.2315","type":"journal-article","created":{"date-parts":[[2016,6,15]],"date-time":"2016-06-15T16:21:37Z","timestamp":1466007697000},"page":"861-863","source":"Crossref","is-referenced-by-count":4,"title":["Durable remission in a patient with leptomeningeal relapse of a MYC\/BCL6\u2010positive double\u2010hit DLBCL treated with lenalidomide monotherapy"],"prefix":"10.1002","volume":"35","author":[{"given":"Massimiliano","family":"Salati","sequence":"first","affiliation":[{"name":"Department of Diagnostic, Clinical, and Public Health Medicine University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittoria","family":"Tarantino","sequence":"additional","affiliation":[{"name":"Department of Diagnostic, Clinical, and Public Health Medicine University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonino","family":"Maiorana","sequence":"additional","affiliation":[{"name":"Department of Diagnostic, Clinical, and Public Health Medicine University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Bettelli","sequence":"additional","affiliation":[{"name":"Department of Diagnostic, Clinical, and Public Health Medicine University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Luminari","sequence":"additional","affiliation":[{"name":"Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.8021"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","unstructured":"SavageKJ SehnLH VillaD et al.The impact of concurrent MYC BCL2 protein expression on the risk of secondary central nervous system relapse in diffuse large B\u2010cell lymphoma (DLBCL).Blood(ASH Annual Meeting Abstracts) 2014; 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