{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:05:01Z","timestamp":1790229901785,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T00:00:00Z","timestamp":1464912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fondazione Cassa di Risparmio di Modena, Modena, Italy"},{"name":"Associazione Angela Serra per la Ricerca sul Cancro, Modena, Italy"},{"name":"Fondazione Italiana Linfomi (FIL), Alessandria, Italy"},{"name":"Allos Therapeutics, Inc., Westminster, CO, USA"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Peripheral T\u2010cell lymphomas (PTCLs) comprise a heterogeneous group of neoplasms that are derived from post\u2010thymic lymphoid cells at different stages of differentiation with different morphological patterns, phenotypes and clinical presentations. PTCLs are highly diverse, reflecting the diverse cells from which they can originate and are currently sub\u2010classified using World Health Organization (WHO) 2008 criteria. In 2006 the International T\u2010Cell Lymphoma Project launched the T\u2010Cell Project, building on the retrospective study previously carried on by the network, with the aim to prospectively collect accurate data to improve knowledge on this group of lymphomas. Based on previously published reports from International Study Groups it emerged that rendering a correct classification of PTCLs is quite difficult because the relatively low prevalence of these diseases results in a lack of confidence by most pathologists. This is the reason why the T\u2010Cell Project requested the availability of diagnostic material from the initial biopsy of each patient registered in the study in order to have the initial diagnosis centrally reviewed by expert hematopathologists. In the present report the results of the review process performed on 573 cases are presented. Overall, an incorrect diagnosis was centrally recorded in 13.1% cases, including 8.5% cases centrally reclassified with a subtype eligible for the project and 4.6% cases misclassified and found to be disorders other than T\u2010cell lymphomas; 2.1% cases were centrally classified as T\u2010Cell disorders not included in the study population. Thus, the T\u2010Cell Project confirmed the difficulties in providing an accurate classification when a diagnosis of PTCLs is suspected, singled out the major pitfalls that can bias a correct histologic categorization and confirmed that a centralized expert review with the application of adequate diagnostic algorithms is mandatory when dealing with these tumours. Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.2316","type":"journal-article","created":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T07:36:03Z","timestamp":1464939363000},"page":"630-636","source":"Crossref","is-referenced-by-count":20,"title":["Pitfalls and major issues in the histologic diagnosis of peripheral T\u2010cell lymphomas: results of the central review of 573 cases from the T\u2010Cell Project, an international, cooperative study"],"prefix":"10.1002","volume":"35","author":[{"given":"Monica","family":"Bellei","sequence":"first","affiliation":[{"name":"Dipartimento di Medicina Diagnostica, Clinica e di Sanit\u00e0 Pubblica Universit\u00e0 di Modena e Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Sabattini","sequence":"additional","affiliation":[{"name":"Policlinico Sant\u2032Orsola\u2009\u2010\u2009Malpighi Unit\u00e0 di Emolinfopatologia  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela Anna","family":"Pesce","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Diagnostica, Clinica e di Sanit\u00e0 Pubblica Universit\u00e0 di Modena e Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Hyeh","family":"Ko","sequence":"additional","affiliation":[{"name":"Samsung General Center, Department of Pathology Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Seog","family":"Kim","sequence":"additional","affiliation":[{"name":"Samsung General Center, Division of Hematology\u2009\u2010\u2009Oncology, Department of Medicine Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elena","family":"Cabrera","sequence":"additional","affiliation":[{"name":"Secci\u00f3n Hematolog\u00eda, Hospedal del Salvator Universidad de Chile  Santiago de Chile Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Martinez","sequence":"additional","affiliation":[{"name":"Instituto de Anatom\u00eda Patologica  Santiago de Chile Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Dlouhy","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Clinic de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Pinto","family":"Paes","sequence":"additional","affiliation":[{"name":"Irmandade da Santa Casa de Misericordia de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Barrese","sequence":"additional","affiliation":[{"name":"Irmandade da Santa Casa de Misericordia de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e8","family":"Vassallo","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Investigative Pathology University of Campinas  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittoria","family":"Tarantino","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Diagnostica, Clinica e di Sanit\u00e0 Pubblica Universit\u00e0 di Modena e Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Vose","sequence":"additional","affiliation":[{"name":"UNMC, Internal Medicine Nebraska Medical Center  Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Weisenburger","sequence":"additional","affiliation":[{"name":"City of Hope National Medical Center  Duarte CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"R\u00fcdiger","sequence":"additional","affiliation":[{"name":"Stadtisches Klinikum Karlsruhe gGmbH Institute of Pathology  Karlsruhe Baden\u2009\u2010\u2009W\u00fcrttemberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Federico","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Diagnostica, Clinica e di Sanit\u00e0 Pubblica Universit\u00e0 di Modena e Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Pileri","sequence":"additional","affiliation":[{"name":"Unit\u00e0 di Diagnosi Emolinfopatologica IEO\u2009\u2010\u2009Istituto Europeo di Oncologia  Milano Italy"},{"name":"Alma mater Professor of Pathology Universit\u00e0 degli Studi di Bologna, Scuola di Medicina e Chirurgia  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh409"},{"key":"e_1_2_7_3_1","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow SH","year":"2008"},{"issue":"1","key":"e_1_2_7_4_1","first-page":"181","article-title":"Immunophenotypic criteria for the diagnosis of non\u2010Hodgkin's lymphoma","volume":"128","author":"Picker LJ","year":"1987","journal-title":"Am J Pathol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.11.4265.bloodjournal88114265"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200007063430107"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200007133430207"},{"issue":"2","key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1182\/blood.V96.2.685.014k26_685_690","article-title":"Expression pattern of T\u2010cell\u2010associated chemokine receptors and their chemokines correlates with specific subtypes of T\u2010cell non\u2010Hodgkin lymphoma","volume":"96","author":"Jones D","year":"2000","journal-title":"Blood"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-09-3080"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.4558"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-008-0062-3"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008265532487"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.5581\/1516-8484.20120013"},{"issue":"13","key":"e_1_2_7_14_1","first-page":"1","article-title":"State of art on T\u2010cell lymphomas: the epidemiology","volume":"2","author":"Liang R","year":"2006","journal-title":"Haematologica Reports"},{"key":"e_1_2_7_15_1","first-page":"306","volume-title":"World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues","author":"Pileri SA","year":"2008"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdf033"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2008.07.010"},{"issue":"12","key":"e_1_2_7_18_1","doi-asserted-by":"crossref","first-page":"4514","DOI":"10.1182\/blood.V89.12.4514","article-title":"Evaluation of the Revised European\u2013American Lymphoma classification confirms the clinical relevance of immunophenotype in 560 cases of aggressive non\u2010Hodgkin's lymphoma","volume":"89","author":"Melnyk A","year":"1997","journal-title":"Blood"},{"issue":"7","key":"e_1_2_7_19_1","first-page":"396","article-title":"Phenotypic analysis of peripheral T cell lymphoma among the Japanese","volume":"43","author":"Nakamura S","year":"1993","journal-title":"Acta Pathol Jpn"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.8.2780"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31821ec4b5"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910600617"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.034199"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pai.0000205062.27174.56"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2508"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190802455867"},{"key":"e_1_2_7_27_1","unstructured":"FedericoM BelleiM PesceEAet al.T\u2010Cell Project: an International Prospective Observational Study of Patients with Aggressive Peripheral T\u2010cell lymphoma. Analysis of first 524 Patients.11th International Conference on Malignant Lymphoma;15\u201318 June;Lugano Switzerland.2011. Abs 241. DOI10.1093\/annonc\/mdr219."},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-2020"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12248"},{"issue":"2","key":"e_1_2_7_30_1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1182\/blood.V83.2.505.505","article-title":"Cytogenetic findings in peripheral T\u2010cell lymphomas as a basis for distinguishing low\u2010grade and high\u2010grade lymphomas","volume":"83","author":"Schlegelberger B","year":"1994","journal-title":"Blood"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07042.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(99)00151-X"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(91)90247-A"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(91)90246-9"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000188"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63742-X"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20386"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2405028"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06924.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-1708"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-10-055145"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-11-536359"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.4474"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26833"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.42.5611"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12880"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon.11.84"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhon.2316","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhon.2316","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.2316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T16:58:51Z","timestamp":1695488331000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.2316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,3]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/hon.2316"],"URL":"https:\/\/doi.org\/10.1002\/hon.2316","archive":["Portico"],"relation":{},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,3]]}}}