{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:43:26Z","timestamp":1786977806028,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,6,24]],"date-time":"2016-06-24T00:00:00Z","timestamp":1466726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Indoleamine 2,3\u2010dioxygenase exerts intense immunomodulatory effects due to enzymatic activities that catalyze the breakdown of the essential amino acid\n                    <jats:sc>l<\/jats:sc>\n                    \u2010tryptophan. The activity of indoleamine 2,3\u2010dioxygenase can be estimated by measuring serum\n                    <jats:sc>l<\/jats:sc>\n                    \u2010kynurenine concentrations. Here, we aimed to determine the role of\n                    <jats:sc>l<\/jats:sc>\n                    \u2010kynurenine as a prognostic factor for peripheral T\u2010cell lymphoma, not otherwise specified (PTCL\u2010NOS) in a retrospective analysis of data derived from 31 consecutive patients between June 2000 and March 2013 who were histologically diagnosed with PTCL\u2010NOS according to the World Health Organization classification and treated with 6\u22128 cycles of cyclophosphamide, doxorubicin or pirarubicin, vincristine, and prednisolone.\n                    <jats:sc>l<\/jats:sc>\n                    \u2010kynurenine concentrations in serum samples collected at admission were measured using high\u2010performance liquid chromatography. The median serum concentration of\n                    <jats:sc>l<\/jats:sc>\n                    \u2010kynurenine was 3.28 (range 0.92\u20138.16)\u2009\u03bcM. The\n                    <jats:sc>l<\/jats:sc>\n                    \u2010kynurenine cutoff was set at 3.07\u2009\u03bcM using receiver operating characteristics curves. The complete remission rates of patients with\n                    <jats:sc>l<\/jats:sc>\n                    \u2010kynurenine &lt;3.07 and \u22653.07\u2009\u03bcM were 69% and 51%, respectively. The 5\u2010year overall survival (OS) rates for patients with\n                    <jats:sc>l<\/jats:sc>\n                    \u2010kynurenine &lt;3.07 and \u22653.07\u2009\u03bcM were 80.2% and 23.4%, respectively (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). More advanced age, poor performance status, elevated lactate dehydrogenase, an unfavorable International Prognostic Index, and a poor prognostic index for T\u2010cell lymphoma were significantly worse factors for OS. Multivariate analyses revealed only\n                    <jats:sc>l<\/jats:sc>\n                    \u2010kynurenine as an independent prognostic factor for OS. In conclusion, serum concentrations of\n                    <jats:sc>l<\/jats:sc>\n                    \u2010kynurenine might comprise a novel prognostic factor with which to determine the outcomes of treatment for PTCL\u2010NOS. Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/hon.2318","type":"journal-article","created":{"date-parts":[[2016,6,25]],"date-time":"2016-06-25T17:47:52Z","timestamp":1466876872000},"page":"637-644","source":"Crossref","is-referenced-by-count":6,"title":["Serum concentrations of\n                    <scp>l<\/scp>\n                    \u2010kynurenine predict clinical outcomes of patients with peripheral T\u2010cell lymphoma, not otherwise specified"],"prefix":"10.1002","volume":"35","author":[{"given":"Yuhei","family":"Shibata","sequence":"first","affiliation":[{"name":"First Department of Internal Medicine Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Hara","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine Gifu University Graduate School of Medicine  Gifu 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