{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:29:11Z","timestamp":1790666951132,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T00:00:00Z","timestamp":1467158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report the case of a patient with a history of Epstein\u2013Barr virus\u2010positive large B\u2010cell lymphoma, who relapsed with an angioimmunoblastic T\u2010cell lymphoma (AITL) associated with a chronic myelomonocytic leukaemia (CMML). We performed targeted next\u2010generation sequencing on CMML and AITL DNA, which revealed mutations of <jats:italic>TET2<\/jats:italic>, <jats:italic>DNMT3A<\/jats:italic>, <jats:italic>SRSF2<\/jats:italic>, <jats:italic>NRAS<\/jats:italic> and <jats:italic>IDH1<\/jats:italic>, thus confirming that the spectrum of AITL mutations share similarities with myeloid disorders. The frequencies of <jats:italic>TET2\/DNMT3A<\/jats:italic> and <jats:italic>SRSF2<\/jats:italic> variants could support the hypothesis that <jats:italic>TET2\/DNMT3A<\/jats:italic> mutations occurred in an early progenitor cell, which later progressed to both the AITL and CMML clones. Treatment with 5\u2010azacytidine led to the complete remission of both diseases. Thus, targeting DNA methylation abnormalities in AITL may be an alternative strategy to chemotherapy. Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.2319","type":"journal-article","created":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T18:49:39Z","timestamp":1467226179000},"page":"864-868","source":"Crossref","is-referenced-by-count":41,"title":["Response to 5\u2010azacytidine in a patient with <i>TET2<\/i>\u2010mutated angioimmunoblastic T\u2010cell lymphoma and chronic myelomonocytic leukaemia preceded by an EBV\u2010positive large B\u2010cell lymphoma"],"prefix":"10.1002","volume":"35","author":[{"given":"Colombe","family":"Saillard","sequence":"first","affiliation":[{"name":"Clinical Hematology, IMAGINE Institute Paris Descartes\u2014Sorbonne Paris Cit\u00e9 University, Necker Hospital, AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene","family":"Guermouche","sequence":"additional","affiliation":[{"name":"Biological Hematology Paris Descartes\u2010Sorbonne Paris Cit\u00e9 University, Cochin 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