{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:10:55Z","timestamp":1766268655555},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,7,12]],"date-time":"2016-07-12T00:00:00Z","timestamp":1468281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Richter syndrome (RS) is the transformation of chronic lymphocytic leukemia in a high\u2010grade lymphoma usually presenting nodal and bone marrow involvement. Richter syndrome can be localized at extranodal sites including the gastrointestinal tract, lungs, and skin. Cutaneous RS is an extremely rare disease apparently showing a less aggressive course than common presentations. While nodal RS has been extensively investigated in literature, pathogenesis and prognosis of cutaneous RS are still partially unknown, even if a role of Epstein\u2010Barr virus infection and p53 disruption has been suggested. Herein, we characterized the histopathological, immunohistochemical features and cytogenetics and molecular alterations of a case of cutaneous RS developed after 8\u00a0years chronic lymphocytic leukemia history. Moreover, we reviewed the literature reports concerning cutaneous RS and made a focus on biological patterns and prognostic implications.<\/jats:p>","DOI":"10.1002\/hon.2327","type":"journal-article","created":{"date-parts":[[2016,7,12]],"date-time":"2016-07-12T07:16:14Z","timestamp":1468307774000},"page":"869-874","source":"Crossref","is-referenced-by-count":5,"title":["Biological and molecular characterization of a rare case of cutaneous Richter syndrome"],"prefix":"10.1002","volume":"35","author":[{"given":"Gianluigi","family":"Reda","sequence":"first","affiliation":[{"name":"OncoHematology Unit, Fondazione Ca' Granda IRCCS Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramona","family":"Cassin","sequence":"additional","affiliation":[{"name":"OncoHematology Unit, Fondazione Ca' Granda IRCCS Ospedale Maggiore Policlinico  Milan Italy"},{"name":"Department of Oncology and Hemato\u2010oncology University of Milan  Milan 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Policlinico  Milan Italy"},{"name":"Department of Oncology and Hemato\u2010oncology University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Orofino","sequence":"additional","affiliation":[{"name":"OncoHematology Unit, Fondazione Ca' Granda IRCCS Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"Gianelli","sequence":"additional","affiliation":[{"name":"Hematopathology Service, Division of Pathology, Department of Pathophysiology and Transplantation, IRCCS Ca' Granda Ospedale Maggiore Policlinico University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonino","family":"Neri","sequence":"additional","affiliation":[{"name":"OncoHematology Unit, Fondazione Ca' Granda IRCCS Ospedale Maggiore Policlinico  Milan Italy"},{"name":"Department of Oncology and Hemato\u2010oncology University of Milan  Milan 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