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However, treatment\u2010induced peripheral neuropathy (TiPN) is a common adverse event associated with them. Risk factors for TiPN in MM patients include advanced age, prior neuropathy, and other drugs, but there are conflicting results about the role of genetics in predicting the risk of TiPN. Thus, we carried out a genome\u2010wide association study based on more than 300\u00a0000 exome single nucleotide polymorphisms in 172 MM patients receiving therapy involving bortezomib and thalidomide. We compared patients developing and not developing TiPN under similar treatment conditions (GEM05MAS65, NCT00443235). The highest\u2010ranking single nucleotide polymorphism was rs45443101, located in the <jats:italic>PLCG2<\/jats:italic> gene, but no significant differences were found after multiple comparison correction (adjusted <jats:italic>P<\/jats:italic>\u00a0=\u00a0.1708). Prediction analyses, cytoband enrichment, and pathway analyses were also performed, but none yielded any significant findings. A copy number approach was also explored, but this gave no significant results either. In summary, our study did not find a consistent genetic component associated with TiPN under bortezomib and thalidomide therapies that could be used for prediction, which makes clinical judgment essential in the practical management of MM treatment.<\/jats:p>","DOI":"10.1002\/hon.2337","type":"journal-article","created":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T05:36:46Z","timestamp":1473313006000},"page":"746-751","source":"Crossref","is-referenced-by-count":27,"title":["Prediction of peripheral neuropathy in multiple myeloma patients receiving bortezomib and thalidomide: a genetic study based on a single nucleotide polymorphism array"],"prefix":"10.1002","volume":"35","author":[{"given":"Ram\u00f3n","family":"Garc\u00eda\u2010Sanz","sequence":"first","affiliation":[{"name":"Hospital Universitario de Salamanca\u2010IBSAL, IBMCC\u2010CSIC  Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis 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