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We retrospectively analyzed data for 29 patients diagnosed with diffuse large B\u2010cell lymphoma or grade 3B follicular lymphoma and treated with rituximab in combination with nonpegylated liposomal doxorubicin between January 2010 and August 2015. The median age was 84\u00a0years. The overall 3\u2010year survival, cause\u2010specific survival, and progression\u2010free survival rates were 46%, 55%, and 44%, respectively. Among prognostic factors, only the achievement of complete remission strongly correlated with overall survival, cause\u2010specific survival, and progression\u2010free survival rates. Treatment caused very mild toxicity, without treatment\u2010related hospitalization or toxic deaths.<\/jats:p>","DOI":"10.1002\/hon.2386","type":"journal-article","created":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T11:33:14Z","timestamp":1486121594000},"page":"44-48","source":"Crossref","is-referenced-by-count":12,"title":["Combination of rituximab and nonpegylated liposomal doxorubicin (<scp>R\u2010NPLD<\/scp>) as front\u2010line therapy for aggressive non\u2010Hodgkin lymphoma (<scp>NHL<\/scp>) in patients 80\u00a0years of age or older: a single\u2010center retrospective study"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1963-6311","authenticated-orcid":false,"given":"Giuseppina","family":"Ricciuti","sequence":"first","affiliation":[{"name":"Center for the Diagnosis and Treatment of Lymphomas, Department of Hematology, Transfusion Medicine and Biotechnology Spirito Santo Hospital  Pescara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica","family":"Finolezzi","sequence":"additional","affiliation":[{"name":"Center for the Diagnosis and Treatment of Lymphomas, Department of Hematology, Transfusion Medicine and Biotechnology Spirito Santo Hospital  Pescara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Luciani","sequence":"additional","affiliation":[{"name":"Center for the Diagnosis and Treatment of Lymphomas, Department of Hematology, Transfusion Medicine and Biotechnology Spirito Santo Hospital  Pescara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Ranucci","sequence":"additional","affiliation":[{"name":"Center for the Diagnosis and Treatment of Lymphomas, Department of Hematology, Transfusion Medicine and Biotechnology Spirito Santo Hospital  Pescara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Federico","sequence":"additional","affiliation":[{"name":"University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Di Nicola","sequence":"additional","affiliation":[{"name":"Department of Medical, Oral and Biotechnological Sciences \u201cG. 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D'Annunzio\u201d University  Chieti Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Angrilli","sequence":"additional","affiliation":[{"name":"Center for the Diagnosis and Treatment of Lymphomas, Department of Hematology, Transfusion Medicine and Biotechnology Spirito Santo Hospital  Pescara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21166"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.57.1.43"},{"key":"e_1_2_6_4_1","first-page":"233","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","year":"2008"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199304083281404"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011795"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.1003"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr411"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm563"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2013.790968"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002770000255"},{"key":"e_1_2_6_12_1","first-page":"958","article-title":"18F\u2010FDG PET for evaluation of bone marrow infiltration in staging of lymphoma: a meta\u2010analysis","volume":"46","author":"Pakos EE","year":"2005","journal-title":"J Nucl Med"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e318168d90b"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"3340","DOI":"10.1182\/blood.V91.9.3340","article-title":"Detection of lymphoma in bone marrow by whole\u2010body positron emission tomography","volume":"91","year":"1998","journal-title":"Blood"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.2403"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-09-524108"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl034"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.658793"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.30.6274"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.08.026"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2014.921914"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-136-2-200201150-00012"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22188"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.08.010"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.02.175"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70069-9"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2011.621565"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11846"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-28-116"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001813-200303000-00008"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2004.08.006"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190802043853"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp544"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2014.11.004"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.050617"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.3947"},{"key":"e_1_2_6_37_1","first-page":"449","article-title":"ABC, GCB, and double\u2010hit diffuse large B\u2010cell lymphoma. 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