{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:08:02Z","timestamp":1790194082859,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T00:00:00Z","timestamp":1493078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Discrimination between lymphoid blast crisis of chronic myeloid leukemia (CML) and de novo <jats:italic>BCR\u2010ABL1<\/jats:italic> positive acute lymphoblastic leukemia (ALL) represents a diagnostic challenge because this distinction has a major incidence on the management of patients. Here, we report an uncommon pediatric case of ALL with cryptic ins(22;9)(q11;q34q34) and p190\u2010type BCR\u2010ABL1 transcript. We performed interphase fluorescence in situ hybridization (FISH) for <jats:italic>BCR\u2010ABL1<\/jats:italic> rearrangement on blood neutrophils, which was positive consistent with the diagnosis of lymphoid blast crisis of CML. This case illustrates the major interest of interphase FISH for <jats:italic>BCR\u2010ABL1<\/jats:italic> rearrangement on blood neutrophils as a decisive method to discriminate a lymphoid blast crisis of CML from a de novo <jats:italic>BCR\u2010ABL1<\/jats:italic> positive ALL.<\/jats:p>","DOI":"10.1002\/hon.2416","type":"journal-article","created":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T07:44:49Z","timestamp":1493192689000},"page":"344-348","source":"Crossref","is-referenced-by-count":14,"title":["Interphase FISH for <i>BCR\u2010ABL1<\/i> rearrangement on neutrophils: A decisive tool to discriminate a lymphoid blast crisis of chronic myeloid leukemia from a de novo <i>BCR\u2010ABL1<\/i> positive acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2634-4288","authenticated-orcid":false,"given":"Estelle","family":"Balducci","sequence":"first","affiliation":[{"name":"APHM, H\u00f4pital La Timone D\u00e9partement de G\u00e9n\u00e9tique M\u00e9dicale  Marseille France"},{"name":"Aix Marseille Univ INSERM, GMGF  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Loosveld","sequence":"additional","affiliation":[{"name":"APHM, H\u00f4pital La Timone Laboratoire d'H\u00e9matologie  Marseille France"},{"name":"Aix Marseille Univ CNRS, INSERM, CIML  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilhem","family":"Rahal","sequence":"additional","affiliation":[{"name":"APHM, H\u00f4pital La Timone Service d'H\u00e9matologie et d'Oncologie P\u00e9diatrique  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Boudjarane","sequence":"additional","affiliation":[{"name":"APHM, H\u00f4pital La Timone D\u00e9partement de G\u00e9n\u00e9tique M\u00e9dicale  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Alazard","sequence":"additional","affiliation":[{"name":"APHM, H\u00f4pital La Timone D\u00e9partement de G\u00e9n\u00e9tique M\u00e9dicale  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Missirian","sequence":"additional","affiliation":[{"name":"APHM, H\u00f4pital La Timone D\u00e9partement de G\u00e9n\u00e9tique M\u00e9dicale  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Lafage\u2010Pochitaloff","sequence":"additional","affiliation":[{"name":"APHM, H\u00f4pital La Timone D\u00e9partement de G\u00e9n\u00e9tique M\u00e9dicale  Marseille France"},{"name":"Aix Marseille Univ CNRS, INSERM, CIML  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard","family":"Michel","sequence":"additional","affiliation":[{"name":"APHM, H\u00f4pital La Timone Service d'H\u00e9matologie et d'Oncologie P\u00e9diatrique  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Zattara","sequence":"additional","affiliation":[{"name":"APHM, H\u00f4pital La Timone D\u00e9partement de G\u00e9n\u00e9tique M\u00e9dicale  Marseille France"},{"name":"Aix Marseille Univ INSERM, GMGF  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,25]]},"reference":[{"issue":"3","key":"e_1_2_7_2_1","first-page":"377","article-title":"The role of BCR\/ABL isoforms in the presentation and outcome of patients with Philadelphia\u2010positive acute lymphoblastic leukemia: a seven\u2010year update of the GIMEMA 0496 trial","volume":"91","author":"Cimino G","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-03-0704"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00193575"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.2177"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000084448"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13896"},{"issue":"10","key":"e_1_2_7_8_1","first-page":"1783","article-title":"Proposals for the immunological classification of acute leukemias. European Group for the Immunological Characterization of Leukemias (EGIL)","volume":"9","author":"Bene M","year":"1995","journal-title":"Leukemia"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-02-204693"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428199309047892"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2004.06.011"},{"key":"e_1_2_7_12_1","article-title":"Nacheva. Significance Analysis of Microarrays (SAM) offers clues to differences between the genomes of adult Philadelphia positive ALL and the lymphoid blast transformation of CML","volume":"173","author":"Grace G","year":"2012","journal-title":"Cancer Informat"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.112912"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.223"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-06-509794"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06866"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000445972"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhon.2416","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.2416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T10:56:23Z","timestamp":1695552983000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.2416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,25]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1002\/hon.2416"],"URL":"https:\/\/doi.org\/10.1002\/hon.2416","archive":["Portico"],"relation":{},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,25]]}}}