{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:59:07Z","timestamp":1787169547946,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T00:00:00Z","timestamp":1493251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Studies that have evaluated the prognostic value of body mass index (BMI) in patients with diffuse large B\u2010cell lymphoma have recently been reported. However, the impact of BMI on survival outcomes remains controversial. We retrospectively analyzed the data of 406 diffuse large B\u2010cell lymphoma patients treated with R\u2010CHOP or R\u2010CHOP\u2013like regimens. The number (%) of patients that were categorized into 1 of 4 groups according to BMI were underweight (&lt;18.5\u00a0kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ), 58 (14.3%); normal weight (\u226518.5 to &lt;25\u00a0kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ), 262 (64.5%); overweight (\u226525 to &lt;30\u00a0kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ), 75 (18.5%); and obese (\u226530.0\u00a0kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ), 11 (2.7%). While the prognosis of overweight patients was good, being similar to that of normal weight, underweight, and obese patients had a worse prognosis (5\u2010y overall survival [OS] was 57.9%, 74.3%, 73.4%, and 40.9% for underweight, normal weight, overweight, and obese patients, respectively;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.004). In multivariate analysis, underweight and obesity were independent prognostic factors for OS compared with normal weight (hazard ratios 2.90 and 5.17, respectively). In elderly female patients (\u226570\u00a0y), patients with a low BMI (&lt;25\u00a0kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ) had significantly inferior OS than those with a high BMI (\u226525\u00a0kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ) (5\u2010y OS, 61.5% vs 85.7%;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.039). In contrast, in young female patients (&lt;70\u00a0years), patients with a low BMI had significantly better OS than those with a high BMI (5\u2010y OS, 88.6% vs 46.4%;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.001). In male patients, there were no differences in the effect of BMI on OS between young and elderly patients. In this study, we demonstrated that being underweight and obese were independent prognostic factors compared with being normal weight. In female patients, BMI had a different impact on the prognosis of young and elderly patients, whereas in male patients, there was no difference in the effect of BMI on prognosis according to age.\n                  <\/jats:p>","DOI":"10.1002\/hon.2426","type":"journal-article","created":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T17:50:27Z","timestamp":1493315427000},"page":"76-83","source":"Crossref","is-referenced-by-count":8,"title":["Analysis of the prognostic value of BMI and the difference in its impact according to age and sex in DLBCL patients"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9809-2008","authenticated-orcid":false,"given":"Yusuke","family":"Kanemasa","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsu","family":"Shimoyama","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Support Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miho","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Sawada","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Omuro","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsunekazu","family":"Hishima","sequence":"additional","affiliation":[{"name":"Department of Pathology Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiharu","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,27]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"233","volume-title":"World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow SH","year":"2008"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011795"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.1003"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70235-2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70002-0"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2011.1.498"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.2100"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt594"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-015-2438-4"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2010.494315"},{"key":"e_1_2_8_12_1","first-page":"1","article-title":"Can body mass index predict the outcome of diffuse large B\u2010cell lymphoma? 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