{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:21:56Z","timestamp":1760955716326,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,5,29]],"date-time":"2017-05-29T00:00:00Z","timestamp":1496016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Myeloproliferative neoplasms are characterized by transduction pathway recognized as mutually exclusive molecular abnormalities such as BCR\u2010ABL translocation, JAK2V617F or JAK2 exon 12 mutations, MPL w515, and CALR mutations. However, in some rare cases, associations of such mutations are found in 1 patient. This can be related to 2 pathologies (at least 2 different clones harboring 2 mutations) or associated mutations in 1 clone. We describe here such an association of CALR and MPL mutations in a patient harboring the second mutation in a subclone during the phenotypic evolution of the myeloproliferative neoplasms.<\/jats:p>","DOI":"10.1002\/hon.2431","type":"journal-article","created":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T04:32:40Z","timestamp":1496118760000},"page":"336-339","source":"Crossref","is-referenced-by-count":5,"title":["Emergence of <scp>MPLW515<\/scp> mutation in a patient with <scp>CALR<\/scp> deletion: Evidence of secondary acquisition of <scp>MPL<\/scp> mutation in the <scp>CALR<\/scp> clone"],"prefix":"10.1002","volume":"36","author":[{"given":"Nicolas","family":"Partouche","sequence":"first","affiliation":[{"name":"Hematology Laboratory Henri Mondor Hospital, AP\u2010HP  Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carole","family":"Conejero","sequence":"additional","affiliation":[{"name":"University Paris\u2010Est Cr\u00e9teil (UPEC)  Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quentin","family":"Barathon","sequence":"additional","affiliation":[{"name":"Hematology Laboratory Henri Mondor Hospital, AP\u2010HP  Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Moroch","sequence":"additional","affiliation":[{"name":"Pathology Unit Henri Mondor Hospital, AP\u2010HP  Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Tulliez","sequence":"additional","affiliation":[{"name":"Hematology Laboratory Henri Mondor Hospital, AP\u2010HP  Cr\u00e9teil France"},{"name":"University Paris\u2010Est Cr\u00e9teil (UPEC)  Cr\u00e9teil France"},{"name":"Department of Clinical Hematology and Cell Therapy Henri Mondor Hospital, AP\u2010HP  Cr\u00e9teil 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