{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:30:21Z","timestamp":1790173821309,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T00:00:00Z","timestamp":1501200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81100352, 81170485, 81170486, 81170488, 81200360, 81370657, and 81470328"],"award-info":[{"award-number":["81100352, 81170485, 81170486, 81170488, 81200360, 81370657, and 81470328"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The incidence of B\u2010cell chronic lymphoproliferative disorders (B\u2010CLPDs) is significantly lower in China than that in western countries. There have been studies involving small cohorts with conflicting results regarding the spectrum of B\u2010CLPDs in China, and the types and immunophenotyping of B\u2010CLPDs in China remain largely unexplored. We conducted a retrospective analysis of 653 cases of B\u2010CLPDs seen in our centre from 2011 to 2015. Four\u2010colour flow cytometry was used to determine the expression of each immunological marker, and the diagnostic values of the immunological markers were also investigated. Chronic lymphocytic leukaemia (CLL) was the most common type of B\u2010CLPD, which was consistent with that in west countries. However, the proportions of CLL (55.9%), follicular lymphoma (2.6%), and hairy cell leukaemia (0.2%) were lower, while the proportion of lymphoplasmacytic lymphoma\/Waldenstr\u00d6m macroglobulinaemia (5.4%) was higher in China, as compared with western countries. With respect to immunophenotypic characteristics, CD23 (31.7%) was more frequently expressed in mantle cell lymphoma (MCL) in our cohort than that in western countries. Immunophenotyping was useful in differentiating MCL from CLL or B\u2010cell prolymphocytic leukaemia and lymphoplasmacytic lymphoma\/Waldenstr\u00d6m macroglobulinaemia from splenic marginal zone lymphoma. CD200 was of better diagnostic performance (accuracy: 94.6%) in differentiating CLL from MCL compared with CD23 (accuracy: 93.3%). Some cases of B\u2010CPLDs, however, had no definite diagnoses, which were diagnosed as CD5\n                    <jats:sup>+<\/jats:sup>\n                    B\u2010CPLDs unclassified (7.7%) and CD5\n                    <jats:sup>\u2212<\/jats:sup>\n                    B\u2010CPLDs unclassified (15.8%). This is the largest study that systematically explores the spectrum and immunophenotyping of B\u2010CLPDs in Asia, confirming that spectrum of B\u2010CLPDs in China was different from that in western countries. The immunophenotypic features of B\u2010CLPDs were similar between China and western countries, although a few disparities exist. Cases with no definite diagnoses warrant further studies in the future.\n                  <\/jats:p>","DOI":"10.1002\/hon.2461","type":"journal-article","created":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T04:48:04Z","timestamp":1501217284000},"page":"121-127","source":"Crossref","is-referenced-by-count":18,"title":["Spectrum and immunophenotyping of 653 patients with B\u2010cell chronic lymphoproliferative disorders in China: A single\u2010centre analysis"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1799-1448","authenticated-orcid":false,"given":"Yi","family":"Miao","sequence":"first","affiliation":[{"name":"Department of Hematology, First Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Hematology, First Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Hematology, First Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Tong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology, First Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, First Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Hematology, First Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, First Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, First Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010Rong","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Hematology, First Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital  Nanjing 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