{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T13:49:39Z","timestamp":1764510579877,"version":"3.37.3"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T00:00:00Z","timestamp":1509321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009950","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NPU I nr.LO1604"],"award-info":[{"award-number":["NPU I nr.LO1604"]}],"id":[{"id":"10.13039\/100009950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","award":["AZV 17\u201028980A"],"award-info":[{"award-number":["AZV 17\u201028980A"]}],"id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Implementation of cytarabine into induction therapy became standard of care for younger patients with mantle cell lymphoma (MCL). On the basis of its beneficial impact, many centers incorporated cytarabine at lower doses also into first\u2010line treatments of elderly patients. We conducted a multicenter observational study that prospectively analyzed safety and efficacy of alternating 3\u00a0+\u00a03\u00a0cycles of R\u2010CHOP and R\u2010cytarabine for newly diagnosed transplant\u2010ineligible MCL patients. A total of 73 patients were enrolled with median age 70\u00a0years. Most patients had intermediate (39.7%) and high\u2010risk (50.7%) disease according to MCL international prognostic index. Rituximab maintenance was initiated in 58 patients. Overall response rate reached 89% by positron emission tomography\u2013computed tomography, including 75.3% complete remissions. Two patients (2.7%) did not complete the induction therapy because of toxicity. Three patients (4.1%) were considered nonresponders, which led to therapy change before completion of induction. Estimated progression\u2010free survival and overall survival were 51.3% and 68.6% at 4\u00a0years, respectively. Mantle cell lymphoma international prognostic index, bulky disease (\u2265 5\u00a0cm), and achievement of positron emission tomography\u2013negativity independently correlated with progression\u2010free survival. Grade 3 to 4 hematologic and nonhematologic toxicity was documented in 48% and 20.5% patients, respectively. Alternation of R\u2010CHOP and R\u2010cytarabine represents feasible and very effective regimen for elderly\/comorbid MCL patients. This study was registered at GovTrial (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>) NCT03054883.<\/jats:p>","DOI":"10.1002\/hon.2483","type":"journal-article","created":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T09:37:10Z","timestamp":1509356230000},"page":"110-115","source":"Crossref","is-referenced-by-count":20,"title":["Alternating <scp>R\u2010CHOP<\/scp> and <scp>R<\/scp>\u2010cytarabine is a safe and effective regimen for transplant\u2010ineligible patients with a newly diagnosed mantle cell lymphoma"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7786-9378","authenticated-orcid":false,"given":"Pavel","family":"Klener","sequence":"first","affiliation":[{"name":"First Medical Department Charles University General Hospital in Prague  Prague Czech Republic"},{"name":"Institute of Pathological Physiology, First Faculty of Medicine Charles University in Prague  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Fronkova","sequence":"additional","affiliation":[{"name":"CLIP, Deparment of Pediatric Hematology\/Oncology Second Faculty of Medicine and University Hospital in Motol  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Belada","sequence":"additional","affiliation":[{"name":"Fourth Department of Internal Medicine\u2014Hematology Charles University Hospital in Hradec Kralove and Faculty of Medicine in Hradec Kralove  Hradec Kr\u00e1lov\u00e9 Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Forsterova","sequence":"additional","affiliation":[{"name":"First Medical Department Charles University General Hospital in Prague  Prague Czech 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Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Salek","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Masaryk University Hospital in Brno  Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi","family":"Mocikova","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Haematology Faculty Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vit","family":"Prochazka","sequence":"additional","affiliation":[{"name":"Department of Hemato\u2010Oncology Faculty of Medicine and Dentistry, Palacky University and University Hospital Olomouc  Olomouc Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Blahovcova","sequence":"additional","affiliation":[{"name":"First Medical Department Charles University General Hospital in Prague  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Janikova","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Masaryk University Hospital in Brno  Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Markova","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Haematology Faculty Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ales","family":"Obr","sequence":"additional","affiliation":[{"name":"Department of Hemato\u2010Oncology Faculty of Medicine and Dentistry, Palacky University and University Hospital Olomouc  Olomouc Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adela","family":"Berkova","sequence":"additional","affiliation":[{"name":"Center of Oncocytogenetics, Institute of Clinical Biochemistry and Laboratory Diagnostics First Faculty of Medicine, Charles University  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jozef","family":"Kubinyi","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Medicine Charles University General Hospital in Prague  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Vaskova","sequence":"additional","affiliation":[{"name":"CLIP, Deparment of Pediatric Hematology\/Oncology Second Faculty of Medicine and University Hospital in Motol  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ester","family":"Mejstrikova","sequence":"additional","affiliation":[{"name":"CLIP, Deparment of Pediatric 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