{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T05:30:31Z","timestamp":1774503031372,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,2,14]],"date-time":"2018-02-14T00:00:00Z","timestamp":1518566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Italian Ministry of Health","award":["580"],"award-info":[{"award-number":["580"]}]},{"name":"Moka Sir's S.p.A."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Enteropathy\u2010associated T\u2010cell lymphoma is regarded as a dismal, late complication of coeliac disease, though a single case of T\u2010cell lymphoma with such features arising in the setting of autoimmune enteropathy of the adult has been reported to date. We aim to describe the case of a 41\u2010year\u2010old woman complaining of severe malabsorption syndrome, who was diagnosed with autoimmune enteropathy based on the presence of flat intestinal mucosa unresponsive to any dietary restriction and positivity for enterocyte autoantibodies. Steroid therapy led to a complete recovery of both mucosal and clinical findings over 12\u00a0years, when disease relapse was accompanied by the appearance of monoclonal rearrangement of T\u2010cell receptor\u2010\u03b3 and peculiar T\u2010cell phenotypic abnormalities, leading to a rapid transition to an overt T\u2010cell lymphoma with features of the enteropathy\u2010associated subtype. Despite intensive treatment, the patient developed cerebral metastasis and died 9\u00a0months later. Our case enhances the concept of enteropathy\u2010associated T\u2010cell lymphoma as a disease that may arise in the setting of enteropathies other than coeliac disease, thus representing a heterogeneous entity. Moreover, our observations support the need of a close follow\u2010up of these patients, coupled with comprehensive characterization of mucosal biopsies.<\/jats:p>","DOI":"10.1002\/hon.2494","type":"journal-article","created":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T04:58:39Z","timestamp":1518670719000},"page":"481-488","source":"Crossref","is-referenced-by-count":22,"title":["Intestinal T\u2010cell lymphoma with enteropathy\u2010associated T\u2010cell lymphoma\u2010like features arising in the setting of adult autoimmune enteropathy"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6297-7576","authenticated-orcid":false,"given":"Rachele","family":"Ciccocioppo","sequence":"first","affiliation":[{"name":"Gastroenterology Unit, Department of Medicine University of Verona and AOUI Borgo Roma  Verona 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