{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:30:07Z","timestamp":1740105007646,"version":"3.37.3"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17K15657"],"award-info":[{"award-number":["17K15657"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Myeloid sarcoma (MS) is a rare condition and is an extramedullary tumour of immature myeloid cells. It is now known that the programmed death 1 (PD\u20101)\/programmed death ligand 1 (PD\u2010L1) pathway suppresses the host antitumor responses and that these products are expressed on both tumour cells and tumour\u2010infiltrating cells in various malignancies. However, little is known about the significance of PD\u20101\/PD\u2010L1 expression on tumour cells and tumour microenvironmental cells in MS. To investigate the clinicopathological significance of PD\u20101\/PD\u2010L1 expression in MS, we analyzed 98 patients by immunohistochemistry. Of these, 10.2% of cases had neoplastic tumour cells positive for PD\u2010L1 (nPD\u2010L1<jats:sup>+<\/jats:sup>). However, the rate of nPD\u2010L1<jats:sup>+<\/jats:sup> was &lt;5% (range: 0.27 to 2.97%). On the other hand, PD\u2010L1 expression on 1 or more of stromal cells in the tumour microenvironment (miPD\u2010L1<jats:sup>+<\/jats:sup>) was observed in 37.8% of cases. Because all nPD\u2010L1<jats:sup>+<\/jats:sup> cases expressed PD\u20101 on less than 5% of tumour cells, we compared the miPD\u2010L1<jats:sup>+<\/jats:sup> and miPD\u2010L1<jats:sup>\u2212<\/jats:sup> groups. There was a correlation between miPD\u2010L1<jats:sup>+<\/jats:sup> status and the number of PD\u20101\u2010expressing tumour \u2010infiltrating lymphocytes (PD\u20101<jats:sup>+<\/jats:sup> TILs; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0229). miPD\u2010L1<jats:sup>+<\/jats:sup> was found to be associated with poorer overall survival and progression\u2010free survival (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.00392, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.00261, respectively). Multivariate analysis also confirmed miPD\u2010L1<jats:sup>+<\/jats:sup> to be an independent poor prognostic factor. In conclusion, our study indicated that the immunotherapy blocking the PD\u20101\/PD\u2010L1 pathway may improve the clinical outcome of MS.<\/jats:p>","DOI":"10.1002\/hon.2506","type":"journal-article","created":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T21:01:20Z","timestamp":1522443680000},"page":"591-599","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Expression of programmed death ligand 1 is associated with poor prognosis in myeloid sarcoma patients"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9040-285X","authenticated-orcid":false,"given":"Keisuke","family":"Kawamoto","sequence":"first","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  Kurume Japan"},{"name":"Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine Niigata University  Niigata 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