{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:29:52Z","timestamp":1740104992553,"version":"3.37.3"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,6,8]],"date-time":"2018-06-08T00:00:00Z","timestamp":1528416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The outcome of patients with relapsed\/refractory classical Hodgkin lymphoma (R\/R cHL) after autologous stem cell transplantation (auto\u2010SCT) is poor. Recently, the anti\u2010CD30 monoclonal antibody\u2010drug conjugate, brentuximab vedotin (BV), has shown remarkable activity in the setting of R\/R cHL. In the pivotal phase II study, BV produced an overall response rate of 75% and a median progression\u2010free survival of 6.7\u00a0months. Although these results have been reproduced by large registry studies, the impact of BV on the overall survival (OS) of patients with R\/R cHL has not been addressed so far. The aim of this study was to examine the impact of BV on OS in the setting of post auto\u2010SCT R\/R cHL. Analysis was performed in a group of patients with R\/R cHL after a previous auto\u2010SCT reported in the Greek registry during the last 2 decades. By using a multivariate model and censoring patients at the time of subsequent allo\u2010SCT or treatment with immune checkpoint inhibitors, we showed that treatment with BV in the posttransplant relapse setting has a positive impact on the outcome and results in significant improvement of OS. To our knowledge, this the first published study, addressing the impact of BV on the OS in the setting of posttransplant relapse.<\/jats:p>","DOI":"10.1002\/hon.2521","type":"journal-article","created":{"date-parts":[[2018,6,8]],"date-time":"2018-06-08T08:25:47Z","timestamp":1528446347000},"page":"645-650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Positive impact of brentuximab vedotin on overall survival of patients with classical Hodgkin lymphoma who relapse or progress after autologous stem cell transplantation: A nationwide analysis"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3522-3680","authenticated-orcid":false,"given":"Panagiotis","family":"Tsirigotis","sequence":"first","affiliation":[{"name":"Second Dept of Internal Medicine Propaedeutic ATTIKO General University Hospital  Athens 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