{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T12:27:37Z","timestamp":1761395257012,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,6,3]],"date-time":"2018-06-03T00:00:00Z","timestamp":1527984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50 CA97274"],"award-info":[{"award-number":["P50 CA97274"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our aim was to evaluate whether quality of life (QOL) scores at diagnosis predict survival among patients with aggressive lymphoma. Newly diagnosed lymphoma patients were prospectively enrolled within 9\u00a0months of diagnosis in the University of Iowa\/Mayo Clinic SPORE and systematically followed for event\u2010free and overall survival (OS). QOL was measured with the Functional Assessment of Cancer Treatment\u2010General (FACT\u2010G), which measures 4 domains: physical, social\/family, emotional, and functional well\u2010being (WB); a single item Linear Analogue Self\u2010Assessment (LASA) measuring overall QOL; and a spiritual WB LASA. From 9\/2002 to 12\/2009, 701 patients with aggressive lymphoma who completed baseline QOL questionnaires were enrolled. At a median follow\u2010up of 71\u00a0months (range 6\u2010128), 316 patients (45%) had an event and 228 patients (33%) died. All baseline QOL measures but emotional WB were significantly associated with OS (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.04); of which all but LASA spiritual remained significant after adjusting for IPI and NHL subtype. The strongest associations were with total FACT\u2010G (adjusted HR\u00a0=\u00a00.86, 95% CI: 0.79\u20100.94, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.00062) and functional WB (adjusted HR\u00a0=\u00a00.88, 95% CI: 0.83\u20100.93, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001). QOL LASA was associated with OS (adjusted HR\u00a0=\u00a00.92, 95% CI: 0.87\u20100.97, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0041). Patients with clinically deficient QOL (overall QOL \u226450) had a median OS of 92\u00a0months compared with 121\u00a0months for patients with QOL &gt;50 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0004). In this large sample of patients with aggressive lymphoma, we found that baseline QOL is independently predictive of OS. QOL should be assessed as a prognostic factor in patients with aggressive lymphoma.<\/jats:p>","DOI":"10.1002\/hon.2522","type":"journal-article","created":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T05:44:06Z","timestamp":1528091046000},"page":"749-756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Quality of life at diagnosis predicts overall survival in patients with aggressive lymphoma"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4518-2309","authenticated-orcid":false,"given":"Carrie A.","family":"Thompson","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen J.","family":"Yost","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J.","family":"Maurer","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristine","family":"Allmer","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umar","family":"Farooq","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology, and Blood and Marrow Transplantation University of Iowa  Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas M.","family":"Habermann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David 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