{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:15:39Z","timestamp":1791512139884,"version":"4.3.4"},"reference-count":61,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,6,3]],"date-time":"2018-06-03T00:00:00Z","timestamp":1527984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Patients with rheumatoid arthritis (RA) have a greater risk of developing both Hodgkin lymphoma (HL) and non\u2010HL than the general population. Non\u2010Hodgkin lymphoma is more common than HL in these patients, and diffuse large B cell lymphoma is the most frequent subtype observed. Although the clinical course of lymphoma in RA is often aggressive, the prognosis in these cases is similar to that of lymphoma in the general population. In this review, we summarize data derived from both retrospective and prospective studies, regarding incidence, pathogenesis, and outcome of lymphomas in RA patients and outline the possible mechanisms and hypotheses linking these 2 disorders. Over the years, 3 main theories have been suggested to explain this association. These hypotheses relate to genetic predisposition, persistence of long standing disease activity with continued immune stimulation, and the role of anti\u2010RA therapy given. A common genetic predisposition linking RA and lymphoma has not been established. As for treatment of RA, this includes immunosuppressive antitumor necrosis factor drugs or conventional disease modifying antirheumatic drugs like methotrexate. Neither of these drug categories appears to be associated with a higher risk of lymphoma in RA. The impact of continuing disease activity and immune stimulation appears to be the most significant in lymphomagenesis in these patients.<\/jats:p>","DOI":"10.1002\/hon.2525","type":"journal-article","created":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T00:48:50Z","timestamp":1528073330000},"page":"733-739","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["Rheumatoid arthritis and lymphoma: Incidence, pathogenesis, biology, and outcome"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5039-1412","authenticated-orcid":false,"given":"Alina","family":"Klein","sequence":"first","affiliation":[{"name":"Medicine A, Rabin Medical Center  Petah\u2010Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Polliack","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hadassah University Hospital Hebrew University Medical School  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat","family":"Gafter\u2010Gvili","sequence":"additional","affiliation":[{"name":"Medicine A, Rabin Medical Center  Petah\u2010Tikva Israel"},{"name":"Sackler School of Medicine  Tel\u2010Aviv Israel"},{"name":"Institute of Hematology Davidoff Cancer Center  Petah\u2010Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,3]]},"reference":[{"issue":"3","key":"e_1_2_6_2_1","first-page":"368","article-title":"One year in review 2017: pathogenesis of rheumatoid arthritis","volume":"35","author":"Angelotti F","year":"2017","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200405000-00014"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.20.2337"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40744-017-0064-4"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0728-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.4.307"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(85)90240-2"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.11.3909"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.030528"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30134"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-010-1524-0"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes350"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27402"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.11144"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2508"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211623"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22277"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.6227"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu144"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10939"},{"issue":"9","key":"e_1_2_6_22_1","first-page":"S188","article-title":"Inflammatory activity, but not methotrexate or prednisone use predicts non\u2010Hodgkin's lymphoma in rheumatoid arthritis: a 25\u2010year study of 1767 RA patients","volume":"41","author":"Wolfe F","year":"1998","journal-title":"Arthritis Rheum"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21675"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2904"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-120-1-199401010-00006"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-12-624304"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar68"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000082106"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23721"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12116"},{"issue":"2","key":"e_1_2_6_31_1","first-page":"322","article-title":"Lymphoproliferative disorders in rheumatoid arthritis: clinicopathological analysis of 76 cases in relation to methotrexate medication","volume":"34","author":"Hoshida Y","year":"2007","journal-title":"J Rheumatol"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20311"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22579"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-017-3634-5"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380815"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.11.005"},{"key":"e_1_2_6_37_1","first-page":"4","article-title":"Unresolved issues in identifying and overcoming inadequate response in rheumatoid arthritis","volume":"81","author":"Cohen SB","year":"2008","journal-title":"J Rheumatol Suppl"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.19.2275"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/2012.jama.10857"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.3816\/CLM.2008.n.009"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.091025"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24506"},{"issue":"2","key":"e_1_2_6_43_1","first-page":"CD008794","article-title":"Adverse effects of biologics","author":"Singh JA","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2009.02296.x"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-009-1233-9"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-1111-4"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.30.4.339"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110982"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-011-1895-y"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-015-3115-7"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204575"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30653"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.126573"},{"issue":"12","key":"e_1_2_6_54_1","first-page":"2398","article-title":"The comparative efficacy and safety of biologics for the treatment of rheumatoid arthritis: a systematic review and metaanalysis","volume":"33","author":"Gartlehner G","year":"2006","journal-title":"J Rheumatol"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.8.3403"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2014.06.012"},{"issue":"5","key":"e_1_2_6_57_1","first-page":"756","article-title":"Risk of malignancy including non\u2010melanoma skin cancers with anti\u2010tumor necrosis factor therapy in patients with rheumatoid arthritis: meta\u2010analysis of registries and systematic review of long\u2010term extension studies","volume":"30","author":"Le Blay P","year":"2012","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048991"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.091466"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30310"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.2217\/ijr.10.44"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209389"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhon.2525","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.2525","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hon.2525","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.2525","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:09:36Z","timestamp":1694736576000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.2525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,3]]},"references-count":61,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1002\/hon.2525"],"URL":"https:\/\/doi.org\/10.1002\/hon.2525","archive":["Portico"],"relation":{},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,3]]},"assertion":[{"value":"2018-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}