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Treatment strategies for FL may include several therapeutic choices, ranging from a \u201cwatchful waiting\u201d approach to stem cell transplantation, mostly depending on staging, age, risk factors, and disease burden at diagnosis. The high radiosensitivity of FL compared with other solid tumors has been known since the beginning of radiotherapy treatment in lymphoma patients. Doses of 24 to 40\u00a0Gy were considered appropriate in first line curative treatment for localized disease (stages I\u2010II), but several publications investigating low\u2010dose radiotherapy (LDRT) of 4Gy (2\u00a0\u00d7\u00a02Gy) reported an overall response rate surprisingly high. Due to its high local efficacy and negligible toxicity, LDRT might be offered to both early and advanced stage FL patients in combination with new agents, at diagnosis or after several lines of systemic therapy. The aim of this review is to summarize and discuss the current knowledge on LDRT for FL and its potential application in a curative setting in combination with new drugs for both early and advanced disease.<\/jats:p>","DOI":"10.1002\/hon.2538","type":"journal-article","created":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T05:07:13Z","timestamp":1535432833000},"page":"723-732","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Renewed interest for low\u2010dose radiation therapy in follicular lymphomas: From biology to clinical applications"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4315-1645","authenticated-orcid":false,"given":"Patrizia","family":"Ciammella","sequence":"first","affiliation":[{"name":"Radiation Oncology Unit AUSL\u2014IRCCS di Reggio Emilia  Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8446-2285","authenticated-orcid":false,"given":"Stefano","family":"Luminari","sequence":"additional","affiliation":[{"name":"Haematology Santa Maria Nuova Hospital, IRCCS  Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9504-991X","authenticated-orcid":false,"given":"Luca","family":"Arcaini","sequence":"additional","affiliation":[{"name":"Hematology Unit Fondazione IRCCS Policlinico S. 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