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In fact, there are many pathological disorders associated with this condition, each of which has distinctive characteristics and requires specific clinical, instrumental, and laboratory assessments to set the appropriate treatment. This review has two aims. Firstly, to provide a framework of the broad spectrum of IgM\u2010associated disorders: (1) monoclonal gammopathy of undetermined significance (MGUS); (2) Waldenstr\u00f6m macroglobulinemia (WM); (3) IgM\u2010related disorders (among which hyperviscosity syndrome, light chain amyloidosis, cold agglutinin disease, cryoglobulinaemia, IgM neuropathy, Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes (POEMS) syndrome, Castleman disease); (4) IgM\u2010secreting multiple myeloma (IgM\u2010MM); and (5) other lymphoproliferative disorders which may be associated with IgM (such as chronic lymphocytic leukemia, small lymphocytic lymphoma, and B\u2010cell non Hodgkin lymphoma). Secondly, to give a detailed insight regarding diagnosis and treatment of WM.<\/jats:p>","DOI":"10.1002\/hon.2539","type":"journal-article","created":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T10:08:51Z","timestamp":1536314931000},"page":"117-128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Diagnostic framing of IgM monoclonal gammopathy: Focus on Waldenstr\u00f6m macroglobulinemia"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8724-2771","authenticated-orcid":false,"given":"Alessandra","family":"Tedeschi","sequence":"first","affiliation":[{"name":"Department of Hematology Niguarda Cancer Center, ASST Grande Ospedale Metropolitano Niguarda  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concetta","family":"Conticello","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Biomedicine, Haematology Section University of Catania  Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Rizzi","sequence":"additional","affiliation":[{"name":"Department of Emergency and Organ Transplantation, Hematology Section University of Bari Medical School  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Benevolo","sequence":"additional","affiliation":[{"name":"Division of Hematology AOU Citt\u00e0 della Salute e della Scienza  Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4527-4131","authenticated-orcid":false,"given":"Luca","family":"Laurenti","sequence":"additional","affiliation":[{"name":"Department of Hematology Catholic University Hospital \u201cA. 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