{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:30:08Z","timestamp":1740105008318,"version":"3.37.3"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T00:00:00Z","timestamp":1536537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adult T\u2010cell leukemia\/lymphoma (ATL) is an aggressive peripheral T\u2010cell neoplasm, and the outcome of patients with ATL after chemotherapy is poor. Allogeneic hematopoietic stem\u2010cell transplantation (allo\u2010HSCT) is a curative treatment modality for ATL, and four factors, namely, age\u00a0&gt;\u00a050\u00a0years, male recipient, lack of complete remission at transplantation, and transplantation of cord blood, were previously shown to be associated with poor survival. We retrospectively analyzed the outcome of 21 patients with ATL who had undergone allo\u2010HSCT at our hospital during a 3\u2010year period. Of 21 patients, all had at least one of the above risk factors, and 18 had two or more. With a median follow\u2010up of 19.7\u00a0months for living patients, the 1\u2010 and 2\u2010year overall survival (OS) rates after transplantation were 34% and 27%, respectively. All relapse\/progression events occurred within 1\u00a0year after allo\u2010HSCT, and the cumulative incidence of relapse\/progression at 1\u00a0year after allo\u2010HSCT was 46.9%. The 100\u2010day and 1\u2010year nonrelapse mortality (NRM) rates were 19% and 42%, respectively. No significant difference in OS was observed between myeloablative and reduced\u2010intensity conditioning regimens. The 3\u2010year OS (27%) of ATL patients who received allo\u2010HSCT and who had at least one adverse factor was somewhat poorer than the 3\u2010year OS of 33% identified in a nationwide study of allo\u2010HSCT in ATL patients in Japan. The high relapse\/progression and NRM rates are major problems to be solved to achieve better outcome.<\/jats:p>","DOI":"10.1002\/hon.2549","type":"journal-article","created":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T02:54:28Z","timestamp":1534474468000},"page":"651-655","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Outcome of allogeneic hematopoietic cell transplantation in patients with adult <scp>T<\/scp>\u2010cell leukemia"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6347-4305","authenticated-orcid":false,"given":"Ayako","family":"Kamiunten","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hematology, Faculty of Medicine University of Miyazaki  Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Sekine","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hematology, Faculty of Medicine University of Miyazaki  Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuro","family":"Kameda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hematology, Faculty of Medicine University of Miyazaki  Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Akizuki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hematology, Faculty of Medicine University of Miyazaki  Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Tahira","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hematology, Faculty of Medicine University of Miyazaki  Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kotaro","family":"Shide","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hematology, Faculty 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