{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T20:10:27Z","timestamp":1760472627105,"version":"3.37.3"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,9,13]],"date-time":"2018-09-13T00:00:00Z","timestamp":1536796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","award":["PROGRES Q26\/LF1","PROGRES Q28\/LF1","NPU I nr. LO1604"],"award-info":[{"award-number":["PROGRES Q26\/LF1","PROGRES Q28\/LF1","NPU I nr. LO1604"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["AZV 17\u201028980A (All rights reserved)"],"award-info":[{"award-number":["AZV 17\u201028980A (All rights reserved)"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rituximab maintenance (RM) prolongs survival of elderly patients with mantle cell lymphoma (MCL). Persistent minimal residual disease (MRD) after induction repeatedly correlated with shorter progression\u2010free survival (PFS). However, none of the published studies analyzed patients treated with RM. The main purpose was to analyze prognostic significance of MRD in the elderly patients with newly diagnosed MCL treated according to the recently published observational trial protocol (alternation of R\u2010CHOP and R\u2010cytarabine, 3\u00a0+\u00a03\u00a0cycles, GovTrial number NCT03054883) at the centers that implemented RM. Minimal residual disease was evaluated by a EuroMRD standardized real\u2010time PCR approach after 3 and 6\u00a0cycles of the induction therapy. Prognostic significance of MRD was analyzed in a subcohort of patients treated at the centers that implemented RM as a standard approach. Bone marrow proved to be a significantly more sensitive source for MRD detection than peripheral blood. In either compartment MRD (positive versus negative) after 3 or 6\u00a0cycles of the induction therapy did not correlate with PFS. The observed loss of prognostic significance of MRD after the R\u2010CHOP\u2010based induction appears to be a consequence of RM immune control over the residual lymphoma.<\/jats:p>","DOI":"10.1002\/hon.2550","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T15:16:55Z","timestamp":1534951015000},"page":"773-778","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Potential loss of prognostic significance of minimal residual disease assessment after R\u2010CHOP\u2010based induction in elderly patients with mantle cell lymphoma in the era of rituximab maintenance"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7786-9378","authenticated-orcid":false,"given":"Pavel","family":"Klener","sequence":"first","affiliation":[{"name":"First Medical Department Charles University General Hospital in Prague  Czech Republic"},{"name":"Institute of Pathological Physiology, First Faculty of Medicine Charles University in Prague  Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Fronkova","sequence":"additional","affiliation":[{"name":"Childhood Leukaemia Investigation Prague (CLIP), Department of Paediatric Haematology and Oncology, Second Faculty of Medicine Charles University and University Hospital Motol  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marketa","family":"Kalinova","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine, Second Faculty of Medicine Charles University Hospital in Motol  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Belada","sequence":"additional","affiliation":[{"name":"Fourth Department of Internal Medicine\u2014Hematology Charles University Hospital in Hradec Kralove and Faculty of Medicine in Hradec Kralove  Czech 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Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Trka","sequence":"additional","affiliation":[{"name":"Childhood Leukaemia Investigation Prague (CLIP), Department of Paediatric Haematology and Oncology, Second Faculty of Medicine Charles University and University Hospital Motol  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Trneny","sequence":"additional","affiliation":[{"name":"First Medical Department Charles University General Hospital in Prague  Czech 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