{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T12:58:06Z","timestamp":1769605086591,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T00:00:00Z","timestamp":1536710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Foundation Research Institute at the Hospital Universitario 12 de Octubre"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with follicular lymphoma (FL) who experience early therapy failure (ETF) within 2\u00a0years of frontline immunochemotherapy have poor overall survival (OS). We analyzed the Grupo Espa\u00f1ol de Linfomas y Trasplantes de M\u00e9dula \u00d3sea registry to determine whether autologous stem cell transplantation (ASCT) is effective in this high\u2010risk subgroup. Patients with non\u2010transformed FL treated with rituximab were included in the analysis. ETF was defined as relapse\/progression within 2\u00a0years of starting first\u2010line therapy. We identified two groups: the ETF cohort (<jats:italic>n<\/jats:italic>\u00a0=\u00a052; 38 transplanted in second complete response [CR2] and 14 transplanted in second partial response [PR2]), and the non\u2010ETF cohort (patients receiving ASCT in either CR2 [<jats:italic>n<\/jats:italic>\u00a0=\u00a014] or PR2 [<jats:italic>n<\/jats:italic>\u00a0=\u00a02], but who did not experience ETF following first\u2010line therapy). There were no differences in 5\u2010year progression\u2010free survival (PFS) (49% vs 60%, respectively, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.49) nor in 5\u2010year OS (81% vs 83%, respectively, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.8) between the ETF and non\u2010ETF cohorts. Moreover, in the subgroup of patients who presented an interval from first relapse after primary treatment to ASCT of &lt;1\u00a0year, there were neither differences in terms of PFS (49% vs 66%, respectively, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.44) nor in OS (86% vs 85%, respectively, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.9) between both cohorts. Patients in the ETF cohort transplanted in CR showed a plateau in the PFS curves beyond 7\u00a0years of follow\u2010up, at 50%. Patients presenting ETF after frontline therapy lack standard therapeutic options. ASCT may be a curative option for ETF in patients who respond to rescue treatments and should be considered an early consolidation option.<\/jats:p>","DOI":"10.1002\/hon.2553","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T15:20:01Z","timestamp":1534951201000},"page":"765-772","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Autologous stem cell transplantation may be curative for patients with follicular lymphoma with early therapy failure who reach complete response after rescue treatment"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0892-8682","authenticated-orcid":false,"given":"Ana","family":"Jim\u00e9nez\u2010Ubieto","sequence":"first","affiliation":[{"name":"Hospital Universitario 12 de Octubre  Madrid 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