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These lesions contain subclones that directly influence survival of patients. Bone marrow biopsies are single\u2010site biopsies and thus cannot contain all information about the tumor. In contrast, liquid biopsies analyze circulating cells and molecules that are secreted from all sites of the tumor. Long noncoding RNA molecules are one class of these molecules. We performed a two\u2010phase biomarker study investigating lncRNA expression profiles in exosomes of peripheral blood serum of newly diagnosed multiple myeloma (MM) patients, monoclonal gammopathy of undetermined significance (MGUS) patients in comparison with healthy donors (HD). Surprisingly, this analysis revealed dysregulation of only one exosomal lncRNA PRINS in MM vs HD. Overall, MM and MGUS patients were distinguished from HD with sensitivity of 84.9% and specificity of 83.3%. Our study suggests a possible diagnostic role for exosomal lncRNA PRINS in monoclonal gammopathies patients.<\/jats:p>","DOI":"10.1002\/hon.2554","type":"journal-article","created":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T19:55:10Z","timestamp":1535140510000},"page":"786-791","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Circulating exosomal long noncoding RNA PRINS\u2014First findings in monoclonal gammopathies"],"prefix":"10.1002","volume":"36","author":[{"given":"Lenka","family":"Sedlarikova","sequence":"first","affiliation":[{"name":"Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine Masaryk University  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bozena","family":"Bollova","sequence":"additional","affiliation":[{"name":"Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine Masaryk University  Brno Czech 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