{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:27:36Z","timestamp":1788838056349,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T00:00:00Z","timestamp":1537315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The macrolide clarithromycin has been reported as active for therapy of mucosa associated lymphoid tissue (MALT) lymphoma. Pharmacokinetic properties, however, require continuous daily intake over a prolonged period of time. As the macrolide azithromycin is characterized by a long half\u2010life as well as potential antineoplastic activity in vitro, we have performed a phase II trial of long\u2010term once\u2010weekly oral azithromycin for treatment of MALT lymphoma. In a 2\u2010stage\u2010design, 16 patients (10 f\/6 m) with histologically verified and measurable MALT lymphoma were included in the first phase of the trial, which could be expanded to a maximum of 46 patients depending on remissions in the first phase. Patients were given oral azithromycin 1500\u00a0mg once\u2010weekly 4 times a month, and restaging was performed after 3 and 6\u00a0months. Two patients had gastric and 14 extragastric MALT lymphoma; 12\/16 patients were treatment\u2010naive and received azithromycin as first line treatment. Tolerance of this regimen was excellent, and 14\/16 patients received 6\u00a0months of treatment as scheduled, while 1 patient each discontinued after 4 (progressive disease) and 1 cycle (personal reasons), respectively. The most commonly observed side effects were mild nausea (n\u00a0=\u00a08) and diarrhea (n\u00a0=\u00a04). Efficacy, however, was low as only 4\/16 patients (25%) responded, with 2 complete and 2 partial remissions, 9 patients (56%) had stable disease, and 3 patients 19%) were rated as progressive disease. As the predefined activity of more than 7\/16 patients responding was not reached, the study was stopped after 16 patients. Although long\u2010term once\u2010weekly oral azithromycin showed some antilymphoma activity, the response rate was below the predefined threshold of interest. However, based on our data, one cannot rule out suboptimal dosing in our study; attempts to study azithromycin at a different mode of application might be warranted in the future.<\/jats:p>","DOI":"10.1002\/hon.2555","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T05:03:25Z","timestamp":1535605405000},"page":"22-26","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Treatment of mucosa associated lymphoid tissue lymphoma with a long\u2010term once\u2010weekly regimen of oral azithromycin: Results from the phase II MALT\u2014A trial"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3240-7385","authenticated-orcid":false,"given":"Heimo","family":"Lagler","sequence":"first","affiliation":[{"name":"Department of Medicine 1, Division of Infectious Diseases and Tropical Medicine Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5490-2371","authenticated-orcid":false,"given":"Barbara","family":"Kiesewetter","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, Division of Oncology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Dolak","sequence":"additional","affiliation":[{"name":"Department of Medicine III, Clinical Division of Gastroenterology and Hepatology1 Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Obermueller","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, Division of Infectious Diseases and Tropical Medicine Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Simonitsch\u2010Klupp","sequence":"additional","affiliation":[{"name":"Department of Pathology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius","family":"Lukas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ortrun","family":"Neuper","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, Division of Oncology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang W.","family":"Lamm","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, Division of Oncology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius E.","family":"Mayerhoefer","sequence":"additional","affiliation":[{"name":"Department of Biomedical Imaging and Image\u2010guided Therapy Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Raderer","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, Division of Oncology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,19]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"214","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC","author":"Isaacson PGCA","year":"2008"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199405053301803"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-12-624304"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21330"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404782"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-119974"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-016-2672-4"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312288"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-102967"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14878"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(96)80179-2"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.1.75"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(01)00430-7"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-199815020-00009"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep07438"},{"key":"e_1_2_5_17_1","article-title":"Macrolide antibiotics for cystic fibrosis","volume":"11","author":"Southern KW","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12078"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv214"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2004.05.011"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-9114.1992.tb04504.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2009.01.014"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12845"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2015-0176"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08179.x"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhon.2555","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.2555","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hon.2555","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.2555","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T14:37:39Z","timestamp":1694356659000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.2555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,19]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1002\/hon.2555"],"URL":"https:\/\/doi.org\/10.1002\/hon.2555","archive":["Portico"],"relation":{},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,19]]},"assertion":[{"value":"2018-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}