{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:25:02Z","timestamp":1790673902237,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T00:00:00Z","timestamp":1541635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mucosa\u2010associated lymphoid tissue (MALT) lymphoma is an indolent lymphoma with good prognosis and variable fluorine\u201018 fluorodeoxyglucose (<jats:sup>18<\/jats:sup>F\u2010FDG) avidity. Many possible prognostic factors have been investigated with controversial results, but the possible prognostic role of <jats:sup>18<\/jats:sup>F\u2010FDG positron emission tomography\/computed tomography (PET\/CT) remains unclear. Our aim was to evaluate the prognostic impact of qualitative and semiquantitative baseline PET\/CT parameters on outcome of MALT lymphoma. We retrospectively enrolled 161 patients with histologically confirmed MALT lymphoma who underwent <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT before any treatment. PET images were qualitatively and semiquantitatively analyzed by measuring the maximum standardized uptake value body weight (SUVbw), lean body mass (SUVlbm), body surface area (SUVbsa), metabolic tumor volume (MTV), and total lesion glycolysis (TLG). The Kaplan\u2010Meier method was used to estimate the progression\u2010free survival (PFS) and overall survival (OS) times. Cox regression models were performed to determine the relation between PET\/CT features and OS and PFS. Ninety\u2010eight patients had positive <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT showing <jats:sup>18<\/jats:sup>F\u2010FDG uptake (mean SUVbw, 10.1; SUVlbm, 7.2; SUVbsa, 2.7; MTV, 88.8; and TLG, 526); the remaining 63 were not <jats:sup>18<\/jats:sup>F\u2010FDG avid. <jats:sup>18<\/jats:sup>F\u2010FDG avidity was significantly correlated with tumor size and Ki\u201067 score. Relapse\/progression of disease occurred in 47 patients with an average time of 40.2\u00a0months; death occurred in 12 patients with an average of 59\u00a0months. At a median follow\u2010up of 62\u00a0months, median PFS and OS were 52 and 62\u00a0months, respectively. Advanced tumor stage and extragastric site were demonstrated to be independent prognostic factors for PFS, while only tumor stage for OS. Instead, PET\/CT parameters were not related to survival, despite positive correlation at univariate analysis between MTV and TLG with PFS and positive PET\/CT with PFS and OS. In conclusion, a 61% rate of PET avidity in biopsy\u2010confirmed MALT lymphoma was found, and it was correlated with tumor size and Ki\u201067 score. Only tumor stage and localization were independently correlated with PFS and OS.<\/jats:p>","DOI":"10.1002\/hon.2563","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T22:27:49Z","timestamp":1539124069000},"page":"39-46","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Prognostic role of baseline <sup>18<\/sup><scp>F<\/scp>\u2010<scp>FDG PET<\/scp>\/<scp>CT<\/scp> parameters in <scp>MALT<\/scp> lymphoma"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0810-6494","authenticated-orcid":false,"given":"Domenico","family":"Albano","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine Spedali Civili di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Bosio","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Spedali Civili di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Camoni","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Spedali Civili di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirko","family":"Farina","sequence":"additional","affiliation":[{"name":"Division of Hematology Spedali Civili di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Re","sequence":"additional","affiliation":[{"name":"Division of Hematology Spedali Civili di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Tucci","sequence":"additional","affiliation":[{"name":"Division of Hematology Spedali Civili di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Giubbini","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University of Brescia and Spedali Civili di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bertagna","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University of Brescia and Spedali Civili di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19831015)52:8<1410::AID-CNCR2820520813>3.0.CO;2-3"},{"key":"e_1_2_8_3_1","volume-title":"Tumours of Haematopoietic and Lymphoid Tissues: World Health Organization Classification of Tumours, Pathology, and Genetics. 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