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In indolent subtypes, regression of NHL was reported after HCV eradication with antiviral therapy (AT). In 2008 in Lombardy, a region of Northern Italy, the <jats:italic>\u201cRete Ematologica Lombarda\u201d<\/jats:italic> (<jats:italic>REL, Hematology Network of Lombardy\u2014Lymphoma Workgroup<\/jats:italic>) started a prospective multicenter observational cohort study on NHL associated with HCV infection, named <jats:italic>\u201cRegistro Lombardo dei Linfomi HCV\u2010positivi\u201d<\/jats:italic> (<jats:italic>\u201cLombardy Registry of HCV\u2010associated non\u2010Hodgkin lymphomas\u201d<\/jats:italic>). Two hundred fifty patients with a first diagnosis of NHL associated with HCV infection were enrolled; also in our cohort, diffuse large B cell lymphoma (DLBCL) and marginal zone lymphoma (MZL) are the two most frequent HCV\u2010associated lymphomas. Two thirds of patients had HCV\u2010positivity detection before NHL; overall, NHL was diagnosed after a median time of 11\u00a0years since HCV survey. Our data on eradication of HCV infection were collected prior the recent introduction of the direct\u2010acting antivirals (DAAs) therapy. Sixteen patients with indolent NHL treated with interferon\u2010based AT as first line anti\u2010lymphoma therapy, because of the absence of criteria for an immediate conventional treatment for lymphoma, had an overall response rate of 90%. After a median follow\u2010up of 7\u00a0years, the overall survival (OS) was significantly longer in indolent NHL treated with AT as first line (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.048); this confirms a favorable outcome in this subset. Liver toxicity was an important adverse event after a conventional treatment in 20% of all patients, in particular among DLBCL, in which it is more frequent the coexistence of a more advanced liver disease. Overall, HCV infection should be consider as an important co\u2010pathology in the treatment of lymphomas and an interdisciplinary approach should be always considered, in particular to evaluate the presence of fibrosis or necroinflammatory liver disease.<\/jats:p>","DOI":"10.1002\/hon.2575","type":"journal-article","created":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T20:03:01Z","timestamp":1549483381000},"page":"160-167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Lymphomas associated with chronic hepatitis C virus infection: A prospective multicenter cohort study from the Rete Ematologica Lombarda (REL) clinical network"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2682-3414","authenticated-orcid":false,"given":"Sara","family":"Rattotti","sequence":"first","affiliation":[{"name":"Division of Hematology Fondazione IRCCS Policlinico San Matteo  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia Valeria","family":"Ferretti","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine University of Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Rusconi","sequence":"additional","affiliation":[{"name":"Division of Hematology Ospedale Niguarda Ca' Granda  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Rossi","sequence":"additional","affiliation":[{"name":"Division of Hematology Ospedali Riuniti  Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Fogazzi","sequence":"additional","affiliation":[{"name":"Division of Hematology Spedali Civili  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Baldini","sequence":"additional","affiliation":[{"name":"Division of Hematology Fondazione IRCCS Ospedale Maggiore Policlinico, Universit\u00e0 degli Studi di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Pioltelli","sequence":"additional","affiliation":[{"name":"Division of Hematology Ospedale S. 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