{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:04:02Z","timestamp":1788919442586,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T00:00:00Z","timestamp":1553040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP17K08736"],"award-info":[{"award-number":["JP17K08736"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hormone therapy has been used for patients with estrogen receptor alpha (ER\u03b1)\u2013positive breast cancers. Recently, some studies reported the expression of ER\u03b1 on neoplastic cells from B\u2010cell lymphomas. However, there has been only one report of ER\u03b1 expression on the follicular dendritic cells (FDCs) that structurally and functionally support the microenvironment of follicular lymphomas (FLs). The objective of this study was to investigate the frequency of ER\u03b1 expression on FDCs in nonneoplastic reactive lymphoid tissues and to compare the frequency of ER\u03b1 expression on FDCs in the axillary lymph nodes between patients with and without antiestrogen therapy and among patients with grades 1\u20103 of FL. Reverse transcription\u2013polymerase chain reaction was performed to detect ER\u03b1 mRNA in FL. In nonneoplastic germinal centers (GCs) from patients with tonsillitis or reactive lymphadenitis, ER\u03b1 was expressed in the light zone. ER\u03b1\u2010positive cells strongly correlated with the width of GCs (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u00a0=\u00a00.81, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) and the CD21\u2010positive (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u00a0=\u00a00.69, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) and CD23\u2010positive (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u00a0=\u00a00.83, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) FDC meshwork. The axillary lymph nodes had fewer ER\u03b1\u2010positive cells, smaller GCs, and a looser CD21\u2010 and CD23\u2010positive FDC meshwork with hormone therapy than without hormone therapy (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Neoplastic follicles of G1\u20102 FL had more ER\u03b1\u2010positive cells and a larger CD23<jats:sup>+<\/jats:sup> FDC meshwork than those of G3 FL (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). ER\u03b1 mRNA was detected in both G1\u20102 FL and G3 FL by reverse transcription\u2013polymerase chain reaction. In conclusion, these results suggested that antiestrogen hormone therapy may decrease the number of ER\u03b1\u2010positive FDCs and that the responses mediated by the estrogen\u2010ER\u03b1 interaction on FDCs may differ between G1\u20102 FL and G3 FL.<\/jats:p>","DOI":"10.1002\/hon.2577","type":"journal-article","created":{"date-parts":[[2019,2,9]],"date-time":"2019-02-09T00:29:26Z","timestamp":1549672166000},"page":"151-159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Differential expression of estrogen receptor\u2013\u03b1 on follicular dendritic cells from patients with grade 1\u20102 and grade 3 follicular lymphoma"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8035-791X","authenticated-orcid":false,"given":"Rintaro","family":"Ohe","sequence":"first","affiliation":[{"name":"Department of Pathological Diagnostics Yamagata University Faculty of Medicine  Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Xue","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Pathology Harbin Medical University Cancer Hospital  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naing","family":"Ye Aung","sequence":"additional","affiliation":[{"name":"Department of Pathological Diagnostics Yamagata University Faculty of Medicine  Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akane","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology Yamagata University Faculty of Medicine  Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanobu","family":"Kabasawa","sequence":"additional","affiliation":[{"name":"Department of Pathological Diagnostics Yamagata University Faculty of Medicine  Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Utsunomiya","sequence":"additional","affiliation":[{"name":"Department of Pathological Diagnostics Yamagata University Faculty of Medicine  Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Tamazawa","sequence":"additional","affiliation":[{"name":"Department of Pathological Diagnostics Yamagata University Faculty of Medicine  Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Pathological Diagnostics Yamagata University Faculty of Medicine  Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Kitaoka","sequence":"additional","affiliation":[{"name":"Department of Pathological Diagnostics Yamagata University Faculty of Medicine  Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Surgery Yonezawa City Hospital  Yonezawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological, General, Breast and Thyroid Surgery Yamagata University Faculty of Medicine  Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Toubai","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology Yamagata University Faculty of Medicine  Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Surgery Yonezawa City Hospital  Yonezawa 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