{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:25:05Z","timestamp":1790673905363,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T00:00:00Z","timestamp":1552867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We evaluated the role of 18\u2010fluoro\u20102\u2010deoxy\u2010<jats:sc>d<\/jats:sc>\u2010glucose positron emission tomography (<jats:sup>[18F]<\/jats:sup> FDG\u2010PET) with computed tomography (CT) (PET\/CT) as a diagnostic and prognostic tool in newly diagnosed marginal zone lymphoma (MZL) patients.<\/jats:p><jats:p>This is a retrospective cohort study of patients with newly diagnosed MZL, treated with immunotherapy, chemotherapy regimens, surgery, or <jats:italic>Helicobacter pylori<\/jats:italic> eradication between 2008 and 2016 in a single tertiary center. Only patients who had a pretreatment PET\/CT (P\u2010PET\/CT) were included. P\u2010PET\/CT, interim (I\u2010PET\/CT), and end\u2010of\u2010treatment PET\/CT (E\u2010PET\/CT) studies were reviewed. P\u2010PET\/CT results were reported using two methods of evaluation, qualitative and semi quantitative: visual assessment (VAS) and maximal standardized uptake value (SUVmax), and I\u2010PET and E\u2010PET results were reported by Deauville 5\u2010point score (DS) evaluation as well. Avidity of PET\/CT was defined as abnormal uptake in any of these methods. The primary outcome was the prognostic role of P\u2010PET\/CT, I\u2010PET\/CT, and E\u2010PET\/CT on progression\u2010free survival (PFS) and overall survival (OS).<\/jats:p><jats:p>Data of 196 patients with MZL were identified, 110 of which had P\u2010PET\/CT and were included in this analysis. Median age was 67\u00a0years (range 18\u201093). The median follow\u2010up period was 63\u00a0months (range 3\u2010278). The median OS and PFS for the whole cohort were 63 (interquartile range 39\u201085) and 60 (interquartile range 37\u201076) months, respectively. The avidity of PET at baseline for the whole cohort was 70% (77\/110 patients), for MALT lymphoma, 62.5% (40\/64 patients), for NMZL, 76.4% (13\/17 patients), and for SMZL, 82.7% (24\/29 patients). When adjusted for IPI, sex, and comorbidities, positive E\u2010PET\/CT was associated with reduced PFS with a hazard ratio (HR) of 3.4 (95% CI, 1.27\u20109.14, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02). Positive E\u2010PET\/CT did not correlate with OS. However, there were only three events. P\u2010PET\/CT was not predictive of PFS or OS. Our study demonstrates that above 70% of MZL are FDG avid. Positive E\u2010PET\/CT is a strong prognostic factor for PFS.<\/jats:p>","DOI":"10.1002\/hon.2578","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T09:19:06Z","timestamp":1549617546000},"page":"168-175","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["FDG PET\/CT as a diagnostic and prognostic tool for the evaluation of marginal zone lymphoma"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8390-064X","authenticated-orcid":false,"given":"Iuliana","family":"Vaxman","sequence":"first","affiliation":[{"name":"Institute of Hematology Davidoff Cancer Center, Rabin Medical Center  Petah\u2010Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Bernstine","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Department of Nuclear Medicine Rabin Medical Center  Petah\u2010Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geffen","family":"Kleinstern","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natav","family":"Hendin","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shai","family":"Shimony","sequence":"additional","affiliation":[{"name":"Institute of Hematology Davidoff Cancer Center, Rabin Medical Center  Petah\u2010Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liran","family":"Domachevsky","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Department of Nuclear Medicine Rabin Medical Center  Petah\u2010Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronit","family":"Gurion","sequence":"additional","affiliation":[{"name":"Institute of Hematology Davidoff Cancer Center, Rabin Medical Center  Petah\u2010Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Groshar","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Department of Nuclear Medicine Rabin Medical Center  Petah\u2010Tikva 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