{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:11:19Z","timestamp":1747149079292,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T00:00:00Z","timestamp":1558656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mantle cell lymphoma (MCL) is an uncommon and typically aggressive form of lymphoma. Although often initially chemosensitive, relapse is common. Several induction and conditioning regimens are used in transplant\u2010eligible patients, and the optimal approach remains unknown. We performed an international, retrospective study of transplant\u2010eligible patients to assess impact of induction chemoimmunotherapy and conditioning regimens on clinical outcomes. We identified 228 patients meeting inclusion criteria. Baseline characteristics were similar among the induction groups except for some variation in age. The type of induction chemoimmunotherapy received did not influence overall response rates (ORRs) (0.43), progression\u2010free survival (PFS) (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.67), or overall survival (OS) (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.35) on multivariate analysis (PFS and OS). Delivery of autologous stem cell transplant (ASCT) was associated with favorable PFS and OS (0.01) on univariate analysis only; this benefit was not seen on multivariate analysis\u2014PFS (0.36) and OS (0.21). Compared with busulfan and melphalan (BuMel), the use of the carmustine, etoposide, cytarabine, melphalan (BEAM)\u2013conditioning regimen was associated with inferior PFS (HR\u00a0=\u00a02.0 [95% CI 1.1\u20103.6], 0.02) but not OS (HR\u00a0=\u00a01.1 [95% CI 0.5\u20102.3], 0.81) on univariate analysis only. Within the limits of a retrospective study and modest power for some comparisons, type of induction therapy did not influence ORR, PFS, or OS for transplant\u2010eligible patients with MCL. International efforts are required to perform randomized clinical trials evaluating chemoimmunotherapy induction regimens.<\/jats:p>","DOI":"10.1002\/hon.2618","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T08:44:18Z","timestamp":1555317858000},"page":"253-260","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A multicenter retrospective comparison of induction chemoimmunotherapy regimens on outcomes in transplant\u2010eligible patients with previously untreated mantle cell lymphoma"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5050-1223","authenticated-orcid":false,"given":"Zi Yun","family":"Ng","sequence":"first","affiliation":[{"name":"Department of Haematology Sir Charles Gairdner Hospital  Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Bishton","sequence":"additional","affiliation":[{"name":"Department of Haematology Nottingham University Hospitals NHS Trust  Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Ritchie","sequence":"additional","affiliation":[{"name":"Department of Haematology, Royal Melbourne Hospital &amp; Peter MacCallum Cancer Centre University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Clinical Haematology, Olivia Newton John Cancer Research and Wellness Centre Austin Health  Heidelberg Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Gilbertson","sequence":"additional","affiliation":[{"name":"Clinical Haematology Monash Health and Monash University  Clayton Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Hill","sequence":"additional","affiliation":[{"name":"Cancer Care Services Princess Alexandra Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumita","family":"Ratnasingam","sequence":"additional","affiliation":[{"name":"Clinical Haematology Monash Health and Monash University  Clayton Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Schwarer","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Eastern Health  Box Hill Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Manos","sequence":"additional","affiliation":[{"name":"Department of Haematology Flinders Medical Centre  Bedford Park South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Shorten","sequence":"additional","affiliation":[{"name":"Department of Haematology St. Vincent's Hospital  Fitzroy Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Haematology Gold Coast University Hospital  Southport Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niles","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Haematology Royal Hobart Hospital  Hobart Tasmania Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Haematology\u2010Oncology, National University Cancer Institute Singapore National University Health System  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"De Mel Widanalage","sequence":"additional","affiliation":[{"name":"Department of Haematology\u2010Oncology, National University Cancer Institute Singapore National University Health System  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tenny","family":"Sunny","sequence":"additional","affiliation":[{"name":"Department of Haematology Fiona Stanley Hospital  Murdoch Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duncan","family":"Purtill","sequence":"additional","affiliation":[{"name":"Department of Haematology Fiona Stanley Hospital  Murdoch Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Poon","sequence":"additional","affiliation":[{"name":"Department of Haematology\u2010Oncology, National University Cancer Institute Singapore National University Health System  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Haematology Royal Hobart Hospital  Hobart Tasmania Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara","family":"Cochrane","sequence":"additional","affiliation":[{"name":"Department of Haematology Gold Coast University Hospital  Southport Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui\u2010Peng","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Haematology Flinders Medical Centre  Bedford Park South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg","family":"Hapgood","sequence":"additional","affiliation":[{"name":"Cancer Care Services Princess Alexandra Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantine","family":"Tam","sequence":"additional","affiliation":[{"name":"Department of Haematology, Royal Melbourne Hospital &amp; 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