{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:54:40Z","timestamp":1790128480139,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T00:00:00Z","timestamp":1563148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Youth Program, grant No. 81500164"],"award-info":[{"award-number":["Youth Program, grant No. 81500164"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500164"],"award-info":[{"award-number":["81500164"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Accumulating studies have focused on circulating microRNAs, which might be potential biomarkers for different malignancies. The aim of this study was to investigate the potential of serum exosomal microRNAs to be novel serum biomarkers for smouldering myeloma (SMM) or even multiple myeloma (MM). The levels of serum exosomal microRNAs and serum circulating microRNAs were measured in healthy individuals and patients with SMM (n = 20) or MM (n = 20). Serum exosomal microRNAs and serum circulating microRNAs were extracted from serum, and the expression levels of selected microRNAs were quantified by real\u2010time polymerase chain reaction (PCR). The levels of serum exosome\u2010derived miR\u201020a\u20105p, miR\u2010103a\u20103p, and miR\u20104505 were significantly different among patients with MM, patients with SMM, and healthy individuals, while there were differences in the levels of let\u20107c\u20105p, miR\u2010185\u20105p, and miR\u20104741 in patients with MM relative to those in SMM patients or healthy controls. Additionally, a significant correlation was rarely found between the levels of serum and exosomal microRNAs. This study shows that serum exosomal microRNAs can be used independently as novel serum biomarkers for MM.<\/jats:p>","DOI":"10.1002\/hon.2639","type":"journal-article","created":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T08:16:54Z","timestamp":1558167414000},"page":"409-417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Serum exosomal microRNAs as novel biomarkers for multiple myeloma"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6974-373X","authenticated-orcid":false,"given":"Zhi\u2010yao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Hematology, Beijing Chaoyang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010chen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology, Beijing Chaoyang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan\u2010ying","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Hematology, Beijing Chaoyang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010xing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology, Beijing Chaoyang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Hematology, Beijing Chaoyang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology, Beijing Chaoyang Hospital Capital Medical University  Beijing 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diagnostic and prognostic value of plasma microRNA\u2010125b\u20105p in patients with multiple myeloma","volume":"16","author":"Jiang Y","year":"2018","journal-title":"Oncol Lett"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2012.03.017"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.01.007"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2006.05.012"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.10.3082"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.1.3"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.11.043"},{"key":"e_1_2_7_25_1","article-title":"Circulating microRNAs combined with PSA for accurate and non\u2010invasive prostate cancer detection","author":"Mello\u2010Grand 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