{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:11:24Z","timestamp":1772118684518,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,7,28]],"date-time":"2019-07-28T00:00:00Z","timestamp":1564272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Based on results of two pilot trials, lenalidomide (LEN) was found to be active and safe as monotherapy and showed an increased response rate of 80% in combination with rituximab (R) for patients with mucosa\u2010associated lymphoid tissue (MALT) lymphoma. While initial results were promising, there are currently no data on long\u2010term outcome, and larger international phase II\/III trials on LEN for indolent lymphoma lack specific subgroup analyses. Thus, we have systematically analyzed 50 patients treated with LEN\u2010based therapy (LEN\u2010monotherapy n = 16, R\u2010LEN n = 34) at the Medical University of Vienna 2009 to 2019 and investigated long\u2010term outcome and relapse patterns. At a follow\u2010up of more than 5 years (median 68 months), 54% of patients are free of relapse, and estimated median progression\u2010free survival (PFS) was 72 months (95%CI 49\u201096). There was no difference in PFS according to stage of disease, i.e. localized versus disseminated disease (\n                    <jats:italic>P<\/jats:italic>\n                    = .67) and previous systemic treatment (\n                    <jats:italic>P<\/jats:italic>\n                    = .16). Interestingly, but with the caveat of the limited number of patients included in this series, primary extragastric disease had a superior PFS compared with gastric lymphoma (\n                    <jats:italic>P<\/jats:italic>\n                    = .04) and also depth of response, i.e. complete or partial response versus stable disease was associated with significantly prolonged PFS (\n                    <jats:italic>P<\/jats:italic>\n                    = .01). We documented four patients (8%) with pronounced improvement of response during follow\u2010up including three patients initially rated as partial remission and finally achieving complete remission at 12 to 32 months. This highlights the potential of delayed responses to LEN treatment. Estimated overall survival at 5 years was excellent at 92%. These \u201creal\u2010world\u201d data confirm long\u2010term activity of LEN in MALT lymphoma.\n                  <\/jats:p>","DOI":"10.1002\/hon.2647","type":"journal-article","created":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T14:47:52Z","timestamp":1562597272000},"page":"345-351","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Prolonged follow\u2010up on lenalidomide\u2010based treatment for mucosa\u2010associated lymphoid tissue lymphoma (MALT lymphoma)\u2014Real\u2010world data from the Medical University of Vienna"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5490-2371","authenticated-orcid":false,"given":"Barbara","family":"Kiesewetter","sequence":"first","affiliation":[{"name":"Department of Medicine I, Clinical Division of Oncology Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Lamm","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Clinical Division of Oncology Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ortrun","family":"Neuper","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Clinical Division of Oncology Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marius E.","family":"Mayerhoefer","sequence":"additional","affiliation":[{"name":"Department of Biomedical Imaging and Image\u2010guided Therapy, Division of Nuclear Medicine Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Simonitsch\u2010Klupp","sequence":"additional","affiliation":[{"name":"Department of Pathology Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Raderer","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Clinical Division of Oncology Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,28]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"259","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Cook 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