{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T05:45:31Z","timestamp":1778564731614,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T00:00:00Z","timestamp":1571616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The association of systemic mastocytosis with another hematologic neoplasia of myeloid or lymphoid origin is recognized as an advanced subvariant of mastocytosis. Here, we report the association of indolent or smoldering systemic mastocytosis with three cases of myelodysplastic\/myeloproliferative neoplasms with ring sideroblasts and thrombocytosis, a recently recognized disease characterized by\n                    <jats:italic>SF3B1<\/jats:italic>\n                    mutations. The hierarchical pattern of\n                    <jats:italic>KIT<\/jats:italic>\n                    ,\n                    <jats:italic>SF3B1<\/jats:italic>\n                    ,\n                    <jats:italic>JAK2<\/jats:italic>\n                    , and additional mutations was studied in whole and fractionated subpopulations of peripheral blood cells and whole bone marrow. In two cases, we could demonstrate a multilineage D816V\n                    <jats:italic>KIT<\/jats:italic>\n                    mutation, involving all myeloid lineages in one patient and also the lymphoid series in the other. Two patients displaying both\n                    <jats:italic>SF3B1<\/jats:italic>\n                    and V617F\n                    <jats:italic>JAK2<\/jats:italic>\n                    mutations had a very poor prognosis. Another patient bearing\n                    <jats:italic>SF3B1<\/jats:italic>\n                    , but not V617F\n                    <jats:italic>JAK2<\/jats:italic>\n                    mutation, had a favorable response to erythropoietin treatment and long survival.\n                  <\/jats:p>","DOI":"10.1002\/hon.2680","type":"journal-article","created":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T03:33:40Z","timestamp":1568604820000},"page":"628-633","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Systemic mastocytosis associated with myelodysplastic\/myeloproliferative neoplasms with ring sideroblasts and thrombocytosis: Report of three cases"],"prefix":"10.1002","volume":"37","author":[{"given":"Elda","family":"Mimiola","sequence":"first","affiliation":[{"name":"Section of Hematology, Multidisciplinary Outpatients Clinics for Mastocytosis, Department of Medicine AOUI  Verona Italy"},{"name":"Department of Immunohematology and Transfusion Medicine ASST  Mantova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8746-9404","authenticated-orcid":false,"given":"Riccardo","family":"Bomben","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Onco\u2010Hematology Unit, Centro di Riferimento Oncologico IRCCS  Aviano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"De Matteis","sequence":"additional","affiliation":[{"name":"Section of Clinical Biochemistry, Department of Life and Reproduction Sciences AOUI  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Perbellini","sequence":"additional","affiliation":[{"name":"Department of Cell Therapy and Hematology Ospedale San Bortolo  Vicenza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1809-284X","authenticated-orcid":false,"given":"Paola","family":"Guglielmelli","sequence":"additional","affiliation":[{"name":"Center of Research and Innovation of Myeloproliferative Neoplasms Careggi University Hospital  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0716-1686","authenticated-orcid":false,"given":"Massimiliano","family":"Bonifacio","sequence":"additional","affiliation":[{"name":"Section of Hematology, Multidisciplinary Outpatients Clinics for Mastocytosis, Department of Medicine AOUI  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Parisi","sequence":"additional","affiliation":[{"name":"Department of Pathology AOUI  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valter","family":"Gattei","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Onco\u2010Hematology Unit, Centro di Riferimento Oncologico IRCCS  Aviano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Zam\u00f2","sequence":"additional","affiliation":[{"name":"Department of Oncology University of Turin  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Mannelli","sequence":"additional","affiliation":[{"name":"Center of Research and Innovation of Myeloproliferative Neoplasms Careggi University Hospital  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s Celestino","family":"Garc\u00eda Montero","sequence":"additional","affiliation":[{"name":"Cancer Research Centre, Cytometry Service and Department of Medicine University of Salamanca  Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2871-9730","authenticated-orcid":false,"given":"Roberta","family":"Zanotti","sequence":"additional","affiliation":[{"name":"Section of Hematology, Multidisciplinary Outpatients Clinics for Mastocytosis, Department of Medicine AOUI  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.119032"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-03-633537"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-643544"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24332"},{"key":"e_1_2_6_6_1","first-page":"54","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Horny 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