{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:43:32Z","timestamp":1784958212997,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T00:00:00Z","timestamp":1573430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Anti\u2010cancer treatment in children can deteriorate gonadal function and affect future fertility. We analyzed the hormonal markers of gonadal function in adolescent leukemia survivors, treated in childhood with different levels of aggressiveness. We analyzed hormone levels in 69 adolescents and young adults, leukemia survivors stratified into standard (SR), intermediate (IR), and high (HR) risk groups, and in 80 healthy controls (38 men) at a similar age. We assessed follicular stimulating hormone (FSH), luteinizing hormone (LH), and inhibin B in the whole group, testosterone in males, and E2 and anti\u2010M\u00fcllerian hormone (AMH) in females. Males classified into HR group presented, in comparison to control, higher levels of FSH, LH, lower inhibin B, and normal testosterone, whereas in SR and IR group, the hormonal values were comparable to the control. In females, in all risk groups, the levels of FSH, LH, E2, and inhibin B were comparable with the control, but the mean AMH levels were slightly lowered. We did not observe the effect of prophylactic cranial irradiation (12 or 18 Gy) or the time of treatment (before vs. during puberty) on hormone levels. In females, a positive correlation was found between the time interval after the end of treatment and AMH levels. Male leukemia survivors having undergone more intensive chemotherapy show the symptoms of disturbed spermatogenesis and need to be followed\u2010up in the future. Women, irrespective of the risk group, can develop the signs of preterm ovarian insufficiency. They should be informed about the impact of the treatment on gonadal function.<\/jats:p>","DOI":"10.1002\/hon.2681","type":"journal-article","created":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T04:35:12Z","timestamp":1568608512000},"page":"609-616","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The influence of different intensity of treatment on hormonal markers of gonadal function in acute lymphoblastic leukemia survivors"],"prefix":"10.1002","volume":"37","author":[{"given":"Maryna","family":"Krawczuk\u2010Rybak","sequence":"first","affiliation":[{"name":"Department of Pediatric Oncology and Hematology Medical University of Bialystok  Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8137-0948","authenticated-orcid":false,"given":"Marcin","family":"P\u0142onowski","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology and Hematology Medical University of Bialystok  Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u017cbieta","family":"Leszczy\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology and Hematology Medical University of Bialystok  Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eryk","family":"Latoch","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology and Hematology Medical University of Bialystok  Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Sawicka\u2010\u017bukowska","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology and Hematology Medical University of Bialystok  Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Muszy\u0144ska\u2010Ros\u0142an","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology and Hematology Medical University of Bialystok  Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanta","family":"Skalska\u2010Sadowska","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology and Hematopoietic Stem Cell Transplantation, Institute of Pediatrics University of Medical Sciences  Poznan Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Wachowiak","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology and Hematopoietic Stem Cell Transplantation, Institute of Pediatrics University of Medical Sciences  Poznan 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of Pediatrics, Hematology and Oncology Medical University of Gdansk  Gdansk Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Stefanowicz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hematology and Oncology Medical University of Gdansk  Gdansk Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwona","family":"Malinowska","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Medical University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"Matysiak","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Medical University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Kotan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, Collegium Medicum 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