{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T04:49:08Z","timestamp":1750481348479,"version":"3.40.5"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007605","name":"Aarhus Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007605","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006426","name":"Eva og Henry Fr\u00e6nkels Mindefond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006426","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004046","name":"Karen Elise Jensens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007605","name":"Aarhus Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007605","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Galectin\u20101 (Gal\u20101) has been associated with adverse prognosis in several cancers including lymphoma entities with CD30 expression. However, Gal\u20101 expression has not been systematically assessed in peripheral T\u2010cell lymphomas (PTCL). Specimens from 169 nodal PTCL were assessed for intratumoural Gal\u20101 expression by immunohistochemistry. Overall survival (OS) in groups exhibiting high and low Gal\u20101 expression was compared in the cohort and in a subset analysis of CD30\u2010positive PTCL only. Gal\u20101 expression was also correlated with biomarkers of the tumour microenvironment. No significant difference in OS based on Gal\u20101 expression was observed in the entire PTCL cohort. However, in the CD30\u2010positive cohort, patients with high Gal\u20101 levels had significantly poorer outcome (5\u2009years OS 10%, 95% confidence interval CI, 1\u201036) than their low Gal\u20101 counterparts (5\u2009years OS 48%, 95% CI, 30\u201064, <jats:italic>P<\/jats:italic> = .021). In univariate analyses age 60 or younger, non\u2010elevated lactate dehydrogenase (LDH), and performance score less than 2 correlated with superior survival but high Gal\u20101 expression significantly predicted adverse outcome at both univariate (HR 2.5, 95% CI, 1.1\u20105.7, <jats:italic>P<\/jats:italic> = .026) and multivariate levels (HR 3.2, 95% CI, 1.2\u20108.5, <jats:italic>P<\/jats:italic> = .017). Tumours with high Gal\u20101 had few cytotoxic T cells in the tumour microenvironment. High intratumoural Gal\u20101 expression before therapeutic intervention correlates with adverse outcome in nodal CD30<jats:sup>+<\/jats:sup>, ALK<jats:sup>\u2212<\/jats:sup> PTCL patients.<\/jats:p>","DOI":"10.1002\/hon.2702","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T14:29:35Z","timestamp":1576247375000},"page":"59-66","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["High intratumoural galectin\u20101 expression predicts adverse outcome in ALK<sup>\u2212<\/sup> ALCL and CD30<sup>+<\/sup> PTCL\u2010NOS"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1100-4747","authenticated-orcid":false,"given":"Johanne Marie","family":"Holst","sequence":"first","affiliation":[{"name":"Department of Hematology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Ludvigsen","sequence":"additional","affiliation":[{"name":"Department of Hematology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen Jacques","family":"Hamilton\u2010Dutoit","sequence":"additional","affiliation":[{"name":"Department of Pathology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Knud","family":"Bendix","sequence":"additional","affiliation":[{"name":"Department of Pathology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trine Lindhardt","family":"Plesner","sequence":"additional","affiliation":[{"name":"Department of Pathology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"N\u00f8rgaard","sequence":"additional","affiliation":[{"name":"Department of Pathology Herlev Hospital  Herlev Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael B.","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Pathology Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torben","family":"Steiniche","sequence":"additional","affiliation":[{"name":"Department of Pathology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel A.","family":"Rabinovich","sequence":"additional","affiliation":[{"name":"Institute of Biology and Experimental Medicine National Council of Scientific and Technical Investigations  Buenos Aires Argentina"},{"name":"Department of Biological Chemistry, School of Exact and Natural Sciences University of Buenos Aires  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"d'Amore","sequence":"additional","affiliation":[{"name":"Department of Hematology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8261-2374","authenticated-orcid":false,"given":"Martin Bjerreg\u00e5rd","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Hematology Aarhus University Hospital  Aarhus 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