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The disease has a relapsing and remitting pattern, coupled with a risk of transformation into an aggressive lymphoma, and considered incurable for most patients. Next\u2010generation sequencing technologies have increased our understanding of the biology and genetic landscape of the disease, identifying potential druggable targets for treatment. Current prognostic models cannot accurately identify patients at risk of early progression and despite the availability of treatment options for relapsed\/refractory disease, rational treatment selection balancing disease control, efficacy with toxicity, and quality of life remain unmet needs. This review provides an overview of biology, prognostication, treatment options, and emerging therapies that provide valid grounds for optimism.<\/jats:p>","DOI":"10.1002\/hon.2711","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T06:12:40Z","timestamp":1577772760000},"page":"213-222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Follicular lymphoma: Update on management and emerging therapies at the dawn of the new decade"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9461-7575","authenticated-orcid":false,"given":"John","family":"Apostolidis","sequence":"first","affiliation":[{"name":"Department of Adult Hematology and Stem Cell Transplantation King Fahad Specialist Hospital  Dammam Saudi 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