{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:11:24Z","timestamp":1772118684667,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,2,16]],"date-time":"2020-02-16T00:00:00Z","timestamp":1581811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We described four patients with diffuse large B\u2010cell lymphoma (DLBCL) carrying t(9;14)(p13;q32) that places the\n                    <jats:italic>PAX5<\/jats:italic>\n                    adjacent to the immunoglobulin heavy chain (\n                    <jats:italic>IGH<\/jats:italic>\n                    ) gene. Ages ranged between 63 and 80, and three were female. One developed a nodal disease, and the other three involved extranodal organs. The lymphoma cells were CD10\n                    <jats:sup>\u2212<\/jats:sup>\n                    \/BCL6\n                    <jats:sup>\u2212<\/jats:sup>\n                    \/MUM1\n                    <jats:sup>+<\/jats:sup>\n                    in three and CD10\n                    <jats:sup>+<\/jats:sup>\n                    \/BCL6\n                    <jats:sup>+<\/jats:sup>\n                    \/MUM1\n                    <jats:sup>+<\/jats:sup>\n                    in one. BCL2 was weak or negative. All had t(9;14)(p13;q32), and three had additional 14q32\/\n                    <jats:italic>IGH<\/jats:italic>\n                    translocations or +der(14)t(9;14)(p13;q32). Fluorescence in situ hybridization using the\n                    <jats:italic>PAX5<\/jats:italic>\n                    break\u2010apart probe showed that the locus was disrupted between the 5\u2032 and 3\u2032 probes or within the 5\u2032 probe. Immunohistochemistry (IHC) using a monoclonal antibody against PAX5 showed strong nuclear positivity in all four patients. Cell block IHC of a CD30\n                    <jats:sup>+<\/jats:sup>\n                    DLBCL cell line, KIS\u20101, which carried the t(9;14)(p13;q32) and\n                    <jats:italic>PAX5<\/jats:italic>\n                    \u2010\n                    <jats:italic>IGH<\/jats:italic>\n                    fusion gene, reproduced the CD10\n                    <jats:sup>\u2212<\/jats:sup>\n                    \/BCL6\n                    <jats:sup>\u2212<\/jats:sup>\n                    \/MUM1\n                    <jats:sup>+<\/jats:sup>\n                    immunophenotype, low\u2010level BCL2, and strong nuclear PAX5. Uniform nuclear positivity of MUM1 in all four cases and KIS\u20101 cells suggest that these lymphomas arose at a late stage of B\u2010cell differentiation, where expression of PAX5 physiologically becomes downregulated. It is therefore possible that high\u2010level PAX5 resulting from t(9;14)(p13;q32) at this stage of differentiation perturbs the plasma cell differentiation program initiated by PAX5 repression, thereby contributing to the development of a fraction of DLBCL.\n                  <\/jats:p>","DOI":"10.1002\/hon.2716","type":"journal-article","created":{"date-parts":[[2020,1,19]],"date-time":"2020-01-19T01:54:47Z","timestamp":1579398887000},"page":"171-180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Diffuse large B\u2010cell lymphoma carrying t(9;14)(p13;q32)\/\n                    <i>PAX5<\/i>\n                    \u2010immunoglobulin heavy chain gene is characterized by nuclear positivity of MUM1 and PAX5 by immunohistochemistry"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4348-4450","authenticated-orcid":false,"given":"Hitoshi","family":"Ohno","sequence":"first","affiliation":[{"name":"Department of Hematology Tenri Hospital  Tenri Japan"},{"name":"Tenri Institute of Medical Research  Tenri Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miho","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Tenri Institute of Medical Research  Tenri Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiyuki","family":"Kishimori","sequence":"additional","affiliation":[{"name":"Tenri Institute of Medical Research  Tenri Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiro","family":"Fukutsuka","sequence":"additional","affiliation":[{"name":"Tenri Institute of Medical Research  Tenri 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