{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:34:32Z","timestamp":1777509272801,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T00:00:00Z","timestamp":1580688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Because the pathogenesis of gastrointestinal follicular lymphoma (GI\u2010FL) remains unclear, no standardized treatment strategy has been established. Of the gastrointestinal lymphomas, gastric mucosa\u2010associated lymphoid tissue lymphomas are strongly associated with\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                    <\/jats:styled-content>\n                    ; hence, the microbiota may be involved in GI\u2010FL pathogenesis. However, the association between GI\u2010FL and the microbiota remains uninvestigated. Therefore, we compared the mucosal microbiotas of GI\u2010FL patients with those of controls to identify microbiota changes in GI\u2010FL patients. Mucosal biopsy samples were obtained from the second portion of the duodenum from 20 GI\u2010FL patients with duodenal lesions and 20 controls. Subsequent 16S rRNA gene sequencing was performed on these samples. QIIME pipeline and LEfSe software were used to analyze the microbiota. The GI\u2010FL patients had significantly lower alpha diversity (\n                    <jats:italic>P<\/jats:italic>\n                    = .049) than did the controls, with significant differences in the microbial composition (\n                    <jats:italic>P<\/jats:italic>\n                    = .023) evaluated by the beta diversity metrics between the two groups. Comparing the taxonomic compositions indicated that the genera\n                    <jats:italic>Sporomusa<\/jats:italic>\n                    ,\n                    <jats:italic>Rothia<\/jats:italic>\n                    , and\n                    <jats:italic>Prevotella<\/jats:italic>\n                    and the family Gemellaceae were significantly less abundant in the GI\u2010FL patients than in the controls. GI\u2010FL patients presented altered duodenal mucosal microbial compositions, suggesting that the microbiota might be involved in the GI\u2010FL pathogenesis.\n                  <\/jats:p>","DOI":"10.1002\/hon.2717","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T07:13:50Z","timestamp":1580195630000},"page":"181-188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Mucosal dysbiosis in patients with gastrointestinal follicular lymphoma"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0151-3321","authenticated-orcid":false,"given":"Keizo","family":"Zeze","sequence":"first","affiliation":[{"name":"Department of Medicine and Clinical Science, Graduate School of Medical Sciences Kyushu University  Fukuoka 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