{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:04:00Z","timestamp":1788919440454,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T00:00:00Z","timestamp":1586736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP17K08736"],"award-info":[{"award-number":["JP17K08736"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19K16577"],"award-info":[{"award-number":["JP19K16577"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Follicular lymphoma (FL) has a meshwork of follicular dendritic cells (FDCs). We previously demonstrated the presence of estrogen receptor alpha (ER\u03b1)\n                    <jats:sup>+<\/jats:sup>\n                    CD23\n                    <jats:sup>+<\/jats:sup>\n                    FDCs in grades 1\u20102 FL. The significance of FDCs as a prognostic factor in FL remains unknown. The current study aimed to compare clinicopathological features, including prognosis, between FL with and without ER\u03b1\n                    <jats:sup>+<\/jats:sup>\n                    FDCs. This study evaluated the clinicopathological significance of ER\u03b1 expression in 70 FL patients by immunostaining. The presence of\n                    <jats:italic>ER\u03b1<\/jats:italic>\n                    mRNA on FDCs from 5 FL patients was confirmed by CD21\/\n                    <jats:italic>ER\u03b1<\/jats:italic>\n                    double staining (immunohistochemistry and in situ hybridization). We defined patients with frequent ER\u03b1 expression as the ER\u03b1\n                    <jats:sup>high<\/jats:sup>\n                    group and those with infrequent ER\u03b1 expression as the ER\u03b1\n                    <jats:sup>low<\/jats:sup>\n                    group. Thirty\u2010two patients were assigned to the ER\u03b1\n                    <jats:sup>high<\/jats:sup>\n                    group (45.7%), and 38 patients were assigned to the ER\u03b1\n                    <jats:sup>low<\/jats:sup>\n                    group (54.3%). Both overall survival (OS) and progression\u2010free survival (PFS) were significantly better in the ER\u03b1\n                    <jats:sup>high<\/jats:sup>\n                    group than in the ER\u03b1\n                    <jats:sup>low<\/jats:sup>\n                    group (OS, log\u2010rank,\n                    <jats:italic>P<\/jats:italic>\n                    = .0465; PFS, log\u2010rank,\n                    <jats:italic>P<\/jats:italic>\n                    = .0336). Moreover, high ER\u03b1 expression on FDCs was an independent prognostic factor for OS in both the univariate ([hazard ratio] HR, 0.163;\n                    <jats:italic>P<\/jats:italic>\n                    = .0260) and multivariate (HR, 0.050;\n                    <jats:italic>P<\/jats:italic>\n                    = .0188) analyses and for PFS in both the univariate (HR, 0.232;\n                    <jats:italic>P<\/jats:italic>\n                    = .0213) and multivariate (HR, 0.084;\n                    <jats:italic>P<\/jats:italic>\n                    = .0243) analyses.\n                    <jats:italic>ER\u03b1<\/jats:italic>\n                    mRNA expression was detected in CD21\n                    <jats:sup>+<\/jats:sup>\n                    FDCs within the neoplastic follicles of FL patients. In conclusion, a neoplastic follicular microenvironment with ER\u03b1\u2010positive FDCs might affect the grade and presence of the follicular pattern of FL and improve patient prognosis.\n                  <\/jats:p>","DOI":"10.1002\/hon.2730","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T10:24:15Z","timestamp":1584699855000},"page":"293-300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Good prognosis for follicular lymphoma with estrogen receptor \u03b1\u2010positive follicular dendritic cells"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8035-791X","authenticated-orcid":false,"given":"Rintaro","family":"Ohe","sequence":"first","affiliation":[{"name":"Department of Pathological Diagnostics Yamagata University Faculty of Medicine  Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Xue","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Pathology Harbin Medical University Cancer Hospital  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akane","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology Yamagata University Faculty of Medicine  Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naing","family":"Ye Aung","sequence":"additional","affiliation":[{"name":"Department of Pathological Diagnostics Yamagata University Faculty of Medicine  Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanobu","family":"Kabasawa","sequence":"additional","affiliation":[{"name":"Department of Pathological Diagnostics Yamagata University Faculty of Medicine  Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Pathological Diagnostics Yamagata University Faculty of Medicine  Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Utsunomiya","sequence":"additional","affiliation":[{"name":"Department of Pathological Diagnostics Yamagata University Faculty of Medicine  Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Tamazawa","sequence":"additional","affiliation":[{"name":"Department of Pathological Diagnostics Yamagata University Faculty of Medicine  Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Department of Pathological Diagnostics Yamagata University Faculty of Medicine  Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Kitaoka","sequence":"additional","affiliation":[{"name":"Department of Pathological Diagnostics Yamagata University Faculty of Medicine  Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazushi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Pathological Diagnostics Yamagata University Faculty of Medicine  Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Yanagiya","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology Yamagata University Faculty of Medicine  Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Toubai","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology Yamagata University Faculty of Medicine  Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Ishizawa","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology Yamagata University Faculty of Medicine  Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsunori","family":"Yamakawa","sequence":"additional","affiliation":[{"name":"Department of Pathological Diagnostics Yamagata University Faculty of Medicine  Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07651.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2015.1107907"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14201"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2011.02736.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-12-4434"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.3991"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00169-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.7534"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12145"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000969"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-08-799080"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-017-3154-z"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.56.1"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.03779.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2577"},{"key":"e_1_2_7_17_1","first-page":"266","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Jaffe ES","year":"2017"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2015.04.004"},{"key":"e_1_2_7_19_1","unstructured":"RasbandWS. ImageJ U. S. 1997\u20102012.http:\/\/imagej.nih.gov\/ij\/"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2016.04.008"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65179-6"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16125"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-03-691345"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.11.002"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2019.05.021"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.2VMA0818-328R"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.127399"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2015.03.002"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2015.01.016"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhon.2730","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.2730","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hon.2730","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002%2Fhon.2730","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.2730","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T06:17:31Z","timestamp":1693808251000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.2730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,13]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1002\/hon.2730"],"URL":"https:\/\/doi.org\/10.1002\/hon.2730","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/HON.2730\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.2730\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.2730\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.2730\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.2730\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.2730\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.2730\/v1\/review2","asserted-by":"object"}]},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,13]]},"assertion":[{"value":"2019-11-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}