{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:46:11Z","timestamp":1786977971468,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T00:00:00Z","timestamp":1588896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Celgene GmbH"},{"name":"Mundipharma GmbH"},{"name":"Onkovis GmbH"},{"name":"Roche Pharma AG"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Waldenstr\u00f6m's macroglobulinaemia (WM) is a rare indolent B\u2010cell lymphoma for which only little prospective phase III evidence exists. Thus, real world data are important to provide insight into treatment and survival. We present here data on choice and outcome of systemic treatment of patients with WM treated in German routine practice. In total, 139 patients with WM who had been documented in the prospective clinical cohort study Tumour Registry Lymphatic Neoplasms (NCT00889798) were included into this analysis. We analysed the most frequently used first\u2010line and second\u2010line treatments between 2009 and 2017 and examined best response, progression\u2010free survival (PFS) and overall survival (OS). Bendamustine plus rituximab, with a median of six cycles, was by far the most frequently used first\u2010line treatment (81%). Second\u2010line treatment was more heterogenous and mainly based on bendamustine, cyclophosphamide\/doxorubicin\/vincristine\/prednisone (CHOP), fludarabine or ibrutinib, the latter approved in 2014. Three\u2010year PFS from start of first\u2010line treatment was 83% (95% confidence interval [CI] 74%\u201088%), 3\u2010year OS was 87% (95% CI 80%\u201092%). These prospective data give valuable insights into the management and outcome of non\u2010selected patients with WM treated in German routine practice. In the lack of prospective phase III clinical trials, real world data can help bridging the gap of evidence.<\/jats:p>","DOI":"10.1002\/hon.2740","type":"journal-article","created":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T04:16:56Z","timestamp":1588911416000},"page":"344-352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Rare lymphomas in routine practice\u2014Treatment and outcome in Waldenstr\u00f6m's macroglobulinaemia in the prospective German Tumour Registry Lymphatic Neoplasms"],"prefix":"10.1002","volume":"38","author":[{"given":"Wolfgang","family":"Knauf","sequence":"first","affiliation":[{"name":"Centrum f\u00fcr H\u00e4matologie und Onkologie Bethanien  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Abenhardt","sequence":"additional","affiliation":[{"name":"Onkologie Gilching  Gilching Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Rainer","family":"Slawik","sequence":"additional","affiliation":[{"name":"Onkologische Schwerpunktpraxis  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute","family":"B\u00fcckner","sequence":"additional","affiliation":[{"name":"H\u00e4matologisch\u2010onkologische Schwerpunktpraxis  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burkhard","family":"Otremba","sequence":"additional","affiliation":[{"name":"Onkologische Praxis Oldenburg Delmenhorst  Oldenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Sauer","sequence":"additional","affiliation":[{"name":"Medizinisches Versorgungszentrum f\u00fcr Blut\u2010 und Krebserkrankungen  Potsdam Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark\u2010Oliver","family":"Zahn","sequence":"additional","affiliation":[{"name":"Medizinisches Versorgungszentrum Onkologische Kooperation  Goslar Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Wetzel","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Health Economics iOMEDICO  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Kaiser\u2010Osterhues","sequence":"additional","affiliation":[{"name":"Medical Department iOMEDICO  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonora","family":"Houet","sequence":"additional","affiliation":[{"name":"Medical Department iOMEDICO  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6098-1301","authenticated-orcid":false,"given":"Norbert","family":"Marschner","sequence":"additional","affiliation":[{"name":"Praxis f\u00fcr Interdisziplin\u00e4re Onkologie und H\u00e4matologie  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the TLN\u2010Group (Tumour Registry Lymphatic Neoplasms)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy146"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2015.03.001"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2018.05.014"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-09-525808"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2007.02.002"},{"key":"e_1_2_11_8_1","volume-title":"Gesellschaft der epidemiologischen Krebsregister in Deutschland e.V., eds. 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