{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:35:37Z","timestamp":1791207337616,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T00:00:00Z","timestamp":1593043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Mantle cell lymphoma (MCL) is a lymphoproliferative disorder characterized by the t(11;14)(q13;q32)\n                    <jats:italic>CCND1\/IGH<\/jats:italic>\n                    translocation. This lymphoma is however extremely heterogeneous in terms of molecular alterations. Moreover, the course of the disease can vary greatly between indolent forms with slow progression and aggressive conditions rapidly pejorative. The identification of early markers allowing to predict individual patients outcome has however been unsuccessful so far. The LyMa trial treated homogeneously a cohort of young MCL patients. This appeared as a good opportunity to search for biomarkers of response to therapy. DNA extracted from diagnostic paraffin\u2010embedded lymph node biopsies from 100 patients with newly diagnosed MCL, homogeneously treated in this prospective clinical trial, were investigated for copy number alterations and copy neutral loss of heterozygosity using the Oncoscan SNP\u2010array scanning the whole genome. An independent confirmatory cohort was used to strengthen the possibly relevant anomalies observed. Here we describe the recurrent anomalies identified with this technique. Deletions of 17p(\n                    <jats:italic>TP53<\/jats:italic>\n                    ) and 9p(\n                    <jats:italic>CDKN2A<\/jats:italic>\n                    ) were more frequent in refractory or early relapsing patients (10%), but had no significant impact in univariate analysis on progression\u2010free (PFS) or overall survival (OS). Regardless of the presence of\n                    <jats:italic>TP53<\/jats:italic>\n                    or\n                    <jats:italic>CDKN2A<\/jats:italic>\n                    deletions, gains in 7p22 (8,5%) were associated with better PFS in univariate but not in multivariate analysis including MCL International Prognostic Index and treatment. Gains of 11q(\n                    <jats:italic>CCDN1<\/jats:italic>\n                    ), suggesting gains of the\n                    <jats:italic>CCND1\/IGH<\/jats:italic>\n                    fusion, were associated with worse OS and PFS in univariate and multivariate analyses. This worse prognosis impact was confirmed by FISH in an independent confirmatory cohort. This work, using a whole genome approach, confirms the broad genomic landscape of MCL and shows that gains of the\n                    <jats:italic>CCND1\/IGH<\/jats:italic>\n                    fusion can be considered as a new prognostic structural variant. Genomic abnormalities of prognostic impact could be useful to strengthen or de\u2010escalate treatment schedules or choosing targeted therapies or CART\u2010cells.\n                  <\/jats:p>","DOI":"10.1002\/hon.2750","type":"journal-article","created":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T22:50:02Z","timestamp":1590792602000},"page":"446-455","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Whole genome copy number analysis in search of new prognostic biomarkers in first line treatment of mantle cell lymphoma. A study by the\n                    <scp>LYSA<\/scp>\n                    group"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0095-6999","authenticated-orcid":false,"given":"Yannick","family":"Le Bris","sequence":"first","affiliation":[{"name":"Hematology Biology Department Nantes University Hospital  Nantes France"},{"name":"CRCINA, INSERM, CNRS, Universit\u00e9 d'Angers, Universit\u00e9 de Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Magrangeas","sequence":"additional","affiliation":[{"name":"CRCINA, INSERM, CNRS, Universit\u00e9 d'Angers, Universit\u00e9 de Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Moreau","sequence":"additional","affiliation":[{"name":"Pathology Department Nantes University Hospital, now in Centre Hospitalier D\u00e9partemental de Vend\u00e9e  La Roche sur Yon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Chiron","sequence":"additional","affiliation":[{"name":"CRCINA, INSERM, CNRS, Universit\u00e9 d'Angers, Universit\u00e9 de Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Gu\u00e9rin\u2010Charbonnel","sequence":"additional","affiliation":[{"name":"CRCINA, INSERM, CNRS, Universit\u00e9 d'Angers, Universit\u00e9 de Nantes  Nantes France"},{"name":"Institut de Canc\u00e9rologie de l'Ouest, U892  Saint\u2010Herblain France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Theisen","sequence":"additional","affiliation":[{"name":"Hematology Biology Department Nantes University Hospital  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Pichon","sequence":"additional","affiliation":[{"name":"Genetic Department Nantes University Hospital  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Canioni","sequence":"additional","affiliation":[{"name":"Pathology Department Necker University Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Burroni","sequence":"additional","affiliation":[{"name":"Pathology Department Cochin University Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Maisonneuve","sequence":"additional","affiliation":[{"name":"Hematology Clinic, Centre Hospitalier D\u00e9partemental de Vend\u00e9e  La Roche sur Yon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Thieblemont","sequence":"additional","affiliation":[{"name":"Clinical Hematology Department Saint Louis University Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0039-1983","authenticated-orcid":false,"given":"Lucie","family":"Oberic","sequence":"additional","affiliation":[{"name":"Clinical Hematology Department IUCT Oncopole, Toulouse University Hospital  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Gyan","sequence":"additional","affiliation":[{"name":"Clinical Hematology Department Tours University Hospital  Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Pellat\u2010Deceunynck","sequence":"additional","affiliation":[{"name":"CRCINA, INSERM, CNRS, Universit\u00e9 d'Angers, Universit\u00e9 de Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Hermine","sequence":"additional","affiliation":[{"name":"Clinical Hematology Department Necker University Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8010-2343","authenticated-orcid":false,"given":"Marie\u2010H\u00e9l\u00e8ne","family":"Delfau\u2010Larue","sequence":"additional","affiliation":[{"name":"Immunology Department Mondor University Hospital  Creteil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7600-3329","authenticated-orcid":false,"given":"Beno\u00eet","family":"Tessoulin","sequence":"additional","affiliation":[{"name":"CRCINA, INSERM, CNRS, Universit\u00e9 d'Angers, Universit\u00e9 de Nantes  Nantes France"},{"name":"Clinical Hematology Department Nantes University Hospital  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6569-7414","authenticated-orcid":false,"given":"Marie\u2010Christine","family":"B\u00e9n\u00e9","sequence":"additional","affiliation":[{"name":"Hematology Biology Department Nantes 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