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This concept is underlined by the strong causal connection of chronic Helicobacter pylori associated gastritis and MALT lymphoma development based on perpetual auto\u2010antigenic stimulation of Helicobacter pylori\u2010specific T\u2010cells, but also its association with further potential infectious triggers and autoimmune disorders for extragastric lymphoma sites. Thus, given the dependency of MALT lymphoma cells on the tumor microenvironment, this specific entity appears highly suitable for immunomodulatory treatment strategies. Several approaches have been assessed in the last years including promising data on immunomodulatory agents \u201cIMiDs\u201d thalidomide and lenalidomide, macrolide antibiotics and antibodies. The aim of the present review is to discuss rationales for immunomodulatory therapies in MALT lymphoma and to present the statu quo on immunomodulatory and therefore chemotherapy\u2010free treatment strategies for these patients.<\/jats:p>","DOI":"10.1002\/hon.2754","type":"journal-article","created":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T11:20:36Z","timestamp":1590751236000},"page":"417-424","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Immunomodulatory treatment for mucosa\u2010associated lymphoid tissue lymphoma (\n                    <scp>MALT<\/scp>\n                    lymphoma)"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5490-2371","authenticated-orcid":false,"given":"Barbara","family":"Kiesewetter","sequence":"first","affiliation":[{"name":"Department of Medicine I, Division of Oncology Medical University of Vienna  Vienna 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