{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:08:45Z","timestamp":1772118525029,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T00:00:00Z","timestamp":1592956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800121"],"award-info":[{"award-number":["81800121"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500127"],"award-info":[{"award-number":["81500127"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Patients with acute myeloid leukemia (AML) evolving from myelodysplastic syndrome (MDS) or higher\u2010risk MDS have limited treatment options and poor prognosis. Our previous single\u2010center study of decitabine followed by low dose idarubicin and cytarabine (D\u2010IA) in patients with myeloid neoplasms showed promising primary results. We therefore conducted a multicenter study of D\u2010IA regimen in AML evolving from MDS and higher\u2010risk MDS. Patients with AML evolving from MDS or refractory anemia with excess blasts type 2 (RAEB\u20102) (based on the 2008 WHO classification) were included. The D\u2010IA regimen (decitabine, 20\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    daily, days 1 to 3; idarubicin, 6 mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    daily, days 4 to 6; cytarabine 25\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    every 12\u2009hours, days 4 to 8; granulocyte colony stimulating factor [G\u2010CSF], 5 \u03bcg\/kg, from day 4 until neutrophil count increased to 1.0\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L) was administered as induction chemotherapy. Seventy\u2010one patients were enrolled and treated, among whom 44 (62.0%) had AML evolving from MDS and 27 (38.0%) had RAEB\u20102. Twenty\u2010eight (63.6%) AML patients achieved complete remission (CR) or complete remission with incomplete blood count recovery (CRi): 14 (31.8%) patients had CR and 14 (31.8%) had CRi. Six (22.2%) MDS patients had CR and 15 (55.6%) had marrow complete remission. The median overall survival (OS) was 22.4 months for the entire group, with a median OS of 24.2 months for AML and 20.0 months for MDS subgroup. No early death occurred. In conclusion, the D\u2010IA regimen was effective and well tolerated, representing an alternative option for patients with AML evolving from MDS or MDS subtype RAEB\u20102.\n                  <\/jats:p>","DOI":"10.1002\/hon.2755","type":"journal-article","created":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T11:20:00Z","timestamp":1590751200000},"page":"531-540","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Epigenetic priming with decitabine followed by low dose idarubicin and cytarabine in acute myeloid leukemia evolving from myelodysplastic syndromes and higher\u2010risk myelodysplastic syndromes: a prospective multicenter single\u2010arm trial"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7920-1395","authenticated-orcid":false,"given":"Xinping","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital, Zhejiang University, School of Medicine  Hangzhou China"},{"name":"MDS Center The First Affiliated Hospital, Zhejiang University, School of Medicine  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital, Zhejiang University, School of Medicine  Hangzhou China"},{"name":"MDS Center The First Affiliated Hospital, Zhejiang University, School of Medicine  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sir Run Run Shaw Hospital, School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of hematology Yinzhou People's Hospital Affiliated to Medical College of Ningbo University  Ningbo 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University, School of Medicine  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital, Zhejiang University, School of Medicine  Hangzhou China"},{"name":"MDS Center The First Affiliated Hospital, Zhejiang University, School of Medicine  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weilai","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital, Zhejiang University, School of Medicine  Hangzhou China"},{"name":"MDS Center The First Affiliated Hospital, Zhejiang University, School of Medicine  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kongfei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of hematology Yinzhou People's Hospital Affiliated to Medical College of Ningbo University  Ningbo 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