{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T17:05:13Z","timestamp":1770915913134,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T00:00:00Z","timestamp":1596067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim was to build a prognostic model to stratify patients at diagnosis into different risk categories. We investigated the prognostic value of functional PET parameters and clinical features in 64 primary breast lymphoma (PBL) patients. With a median follow\u2010up of 60\u2009months, 5\u2010year progression\u2010free survival (PFS) and overall survival (OS) was 62.5% and 73.4%. In multivariate analysis, baseline total metabolic tumor volume (TMTV0) and \u03b22\u2010microglobulin remained more reliable predictors of survival than other prognostic factors. The optimal TMTV0 cut\u2010off value was 90\u2009cm<jats:sup>3<\/jats:sup>. Among 29 patients with high TMTV0, 5\u2010year PFS and OS were 44.8% and 62.1%, respectively, while 5\u2010year PFS and OS of 35 patients with low TMTV0 were 74.3% and 85.7%, respectively. TMTV0 combined with \u03b22\u2010microglobulin identified three groups with very different prognosis, including low\u2010risk group with low TMTV0 and \u03b22\u2010microglobulin\u2264normal (n = 30), intermediate\u2010risk group with high TMTV0 or \u03b22\u2010microglobulin&gt;normal (n = 20), and high\u2010risk group with high TMTV0 and \u03b22\u2010microglobulin&gt;normal (n = 14). In the three groups, 5\u2010year PFS rates were 80%, 55% and 28.6% (<jats:italic>P<\/jats:italic> = .003), and 5\u2010year OS rates were 90%, 65%, and 50% (<jats:italic>P<\/jats:italic> = .023) respectively. We established a new prognostic model through TMTV0 and \u03b22\u2010microglobulin, and can divide PBL at diagnosis into different risk categories.<\/jats:p>","DOI":"10.1002\/hon.2763","type":"journal-article","created":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T11:30:29Z","timestamp":1592047829000},"page":"493-500","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Combination of baseline total metabolic tumor volume measured on <scp>FDG\u2010PET<\/scp>\/<scp>CT<\/scp> and \u03b22\u2010microglobulin have a robust predictive value in patients with primary breast lymphoma"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8223-5679","authenticated-orcid":false,"given":"Peiqi","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Lymphoma, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University  Tianjin P.R. 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