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Liposomal doxorubicin has been proven to reduce cardiotoxicity. The aim of this retrospective study was the use of nonpeghylated liposomal doxorubicin (NPLD) in term of efficacy, response rate and incidence of cardiac events. We retrospectively collected the experience of 33 Hematological Italian Centers in using NPLD. Nine hundred and forty\u2010six consecutive pts treated with R\u2010COMP (doxorubicin was substituted with NPLD, Myocet) were collected. Median age was 74\u2009years, the reasons for use of NPLD were: age (466 pts), cardiac disease (298 pts), uncontrolled hypertension (126 pts), other reasons (56 pts). According to clinicians' evaluation, 49.9% of pts would not have used standard doxorubicin for different situations (age, cardiomyopathy, previous use of doxorubicin, and uncontrolled hypertension). Overall 687 pts (72.6%) obtained a complete remission (CR). About 5% (n = 51) of subjects developed major cardiotoxic events including heart failure (N = 31), ischemic heart disease (N = 16), acute heart attack (N = 3), and acute pulmonary oedema (N = 1). After a median follow\u2010up of 32\u2009months, 651 pts were alive and the overall survival (OS) was 72%. After a median observation period of 23\u2009months disease free survival (DFS) was 58%. Either in univariate or in multivariate analysis OS and DFS were not significantly affected by age or cardiac disease. Our findings strongly support that including R\u2010COMP is effective and safe when the population is at high risk of cardiac events and negatively selected. Moreover, the use of this NPLD permitted that about half of our population had the opportunity to receive the best available treatment.<\/jats:p>","DOI":"10.1002\/hon.2764","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T07:31:33Z","timestamp":1592292693000},"page":"478-486","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Nonpeghylated liposomal doxorubicin combination regimen (\n                    <scp>R\u2010COMP<\/scp>\n                    ) for the treatment of lymphoma patients with advanced age or cardiac comorbidity"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9320-9334","authenticated-orcid":false,"given":"Luigi","family":"Rigacci","sequence":"first","affiliation":[{"name":"UOC Ematologia e Centro Trapianto Cellule Staminali, AO San Camillo Forlanini Roma  Roma Italy"},{"name":"SOD C Ematologia, AOU Careggi  Firenze Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3095-5313","authenticated-orcid":false,"given":"Ombretta","family":"Annibali","sequence":"additional","affiliation":[{"name":"Ematologia, Trapianto Cellule Staminali, Medicina Trasfusionale, Policlinico Universitario Campus Biomedico  Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofya","family":"Kovalchuk","sequence":"additional","affiliation":[{"name":"SOD C Ematologia, AOU Careggi  Firenze Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Bonifacio","sequence":"additional","affiliation":[{"name":"Ematologia e Trapianto Midollo Osseo, Ospedale Santa Maria della Misericordia, Azienda Ospedaliera Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Pregnolato","sequence":"additional","affiliation":[{"name":"Istituto Auxologico Italiano (IRCCS) Experimental Laboratory of Immunorheumatology, Cusano Milanino  Milanino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Angrilli","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa Semplice Dipartimentale Centro Diagnosi e Terapia Linfomi, Presidio Ospedaliero  Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Vitolo","sequence":"additional","affiliation":[{"name":"SC di Ematologia, AOU Citt\u00e0 della Salute e delle Scienze di Torino  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Pozzi","sequence":"additional","affiliation":[{"name":"Dipartimento Onco\u2010ematologico, Policlinico di Modena Univesrit\u00e0 di Modena e Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Broggi","sequence":"additional","affiliation":[{"name":"Ematologia e Trapianto Midollo Osseo, Ospedale Santa Maria della Misericordia, Azienda Ospedaliera Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Luminari","sequence":"additional","affiliation":[{"name":"Dipartimento Onco\u2010ematologico, Policlinico di Modena Univesrit\u00e0 di Modena e Reggio Emilia  Modena Italy"},{"name":"Unit\u00e0 Operativa di Ematologia, Arcispedale S. 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