{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:29:00Z","timestamp":1790314140529,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T00:00:00Z","timestamp":1596067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Among patients with advanced\u2010stage classical Hodgkin lymphoma (cHL) receiving ABVD chemotherapy, PET performed after the first two treatment cycles (PET\u20102) has prognostic value. However, 15% of patients with a negative PET\u20102 will experience treatment failure. Here we prospectively evaluated serum thymus and activation\u2010regulated chemokine (TARC) levels, to improve risk assessment in patients treated according to HD0607 PET\u2010driven trial (#NCT00795613). In 266 patients with available serum samples, who have agreed to participate in a sub\u2010study for assessment of the role of TARC monitoring, serum TARC levels were measured at baseline and at time of PET\u20102 by commercially available ELISA test kits. The primary end\u2010point was to evaluate the association between TARC after 2 ABVD cycles and PFS. Median TARC\u20102 values were significantly higher in PET\u20102\u2010positive patients compared to PET\u20102\u2010negative patients (\n                    <jats:italic>P<\/jats:italic>\n                    = .001), and in patients with treatment failure compared to those in continuous CR (\n                    <jats:italic>P<\/jats:italic>\n                    = .01). The 4\u2010year PFS significantly differed between patients with TARC\u20102 &gt;800\u2009pg\/mL vs \u2264800\u2009pg\/mL (64% vs 86%,\n                    <jats:italic>P<\/jats:italic>\n                    = .0001). Moreover, among PET\u20102\u2010negative patients, elevated TARC\u20102 identified those with a worse prognosis (74% vs 89%; P = .01). In multivariable analysis, TARC\u20102 &gt;800\u2009pg\/mL was a significant independent predictor of PFS in the whole study population (HR 2.39,\n                    <jats:italic>P<\/jats:italic>\n                    = .004) and among the PET\u20102\u2010negative patients (HR 2.49,\n                    <jats:italic>P<\/jats:italic>\n                    = .02). In conclusion, our results indicate that TARC\u20102 serum levels above 800\u2009pg\/mL suggest the need for a stringent follow\u2010up in PET\u20102\u2010negative patients, and the evaluation of new drugs in PET\u20102\u2010positive, who will likely fail to respond to intensification with escalated BEACOPP.\n                  <\/jats:p>","DOI":"10.1002\/hon.2775","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T08:47:57Z","timestamp":1593506877000},"page":"501-508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Early serum\n                    <scp>TARC<\/scp>\n                    reduction predicts prognosis in advanced\u2010stage\n                    <scp>Hodgkin<\/scp>\n                    lymphoma patients treated with a\n                    <scp>PET<\/scp>\n                    \u2010adapted strategy"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5014-9546","authenticated-orcid":false,"given":"Simonetta","family":"Viviani","sequence":"first","affiliation":[{"name":"Department of Hemato\u2010Oncology Fondazione IRCCS Istituto Nazionale dei Tumori  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arabella","family":"Mazzocchi","sequence":"additional","affiliation":[{"name":"Immuno\u2010hematology and Transfusion Medicine Service Fondazione IRCCS Istituto Nazionale dei Tumori  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Pavoni","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Taverna","sequence":"additional","affiliation":[{"name":"Immuno\u2010hematology and Transfusion Medicine Service Fondazione IRCCS Istituto Nazionale dei Tumori  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Patti","sequence":"additional","affiliation":[{"name":"Division of Hematology 1 Azienda Ospedali Riuniti Villa Sofia\u2010Cervello  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Romano","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgery Science, Hematology Unit University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livio","family":"Trentin","sequence":"additional","affiliation":[{"name":"Department of Hematology University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Sorasio","sequence":"additional","affiliation":[{"name":"Division of Hematology Azienda Ospedaliera Santa Croce e Carle  Cuneo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Guidetti","sequence":"additional","affiliation":[{"name":"Department of Hemato\u2010Oncology Fondazione IRCCS Istituto Nazionale dei Tumori  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Gottardi","sequence":"additional","affiliation":[{"name":"Division of Hematology Ospedale Mauriziano Umberto I di Torino  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Tarella","sequence":"additional","affiliation":[{"name":"Hemato\u2010Oncology Division European Institute of Oncology IRCCS  Milan Italy"},{"name":"University Department \u201cScienze della Salute\u201d (DISS) University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Cimminiello","sequence":"additional","affiliation":[{"name":"Divisione Universitaria di Ematologia Ospedale San Carlo  Potenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2871-9730","authenticated-orcid":false,"given":"Roberta","family":"Zanotti","sequence":"additional","affiliation":[{"name":"Hematology Unit, Department of Medicine Azienda Ospedaliera Universitaria Integrata di Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Farina","sequence":"additional","affiliation":[{"name":"Department of Hemato\u2010Oncology Fondazione IRCCS Istituto Nazionale dei Tumori  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9606-6124","authenticated-orcid":false,"given":"Andr\u00e9s Jos\u00e9 Maria","family":"Ferreri","sequence":"additional","affiliation":[{"name":"Lymphoma Unit, Department of Onco\u2010Hematology IRCCS Istituto di Ricovero e Cura a Carattere Scientifico Ospedale San Raffaele  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Galbiati","sequence":"additional","affiliation":[{"name":"Immuno\u2010hematology and Transfusion Medicine Service Fondazione IRCCS Istituto Nazionale dei Tumori  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Corradini","sequence":"additional","affiliation":[{"name":"Department of Hemato\u2010Oncology Fondazione IRCCS Istituto Nazionale dei Tumori  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro Massimo","family":"Gianni","sequence":"additional","affiliation":[{"name":"Department of Hemato\u2010Oncology Fondazione IRCCS Istituto Nazionale dei Tumori  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gallamini","sequence":"additional","affiliation":[{"name":"Division of Hematology Azienda Ospedaliera Santa Croce e Carle  Cuneo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Rambaldi","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII  Bergamo Italy"},{"name":"Department of Oncology and Hematology University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-0100"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06964.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65424-7"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10218"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-09-112128"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/13.S1.52"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.053199"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-2693"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-1879"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23361"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2017.09.018"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2013.820287"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.08.016"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16514"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.63.1119"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000719"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1510093"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.75.2543"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30784-8"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-017-3690-8"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.116.181347"},{"issue":"9","key":"e_1_2_8_23_1","first-page":"1","article-title":"Interim 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